| 摘要: |
| 目的 评价麻醉诱导后静脉注射50mg/kg硫酸镁对患者术中异丙酚及瑞芬太尼用量及术后不良反应的影响。方法 选取择期全麻下行颅脑部手术，美国麻醉师协会（American Society of Anesthesiologists，ASA）分级Ⅰ或Ⅱ级的成年患者60例（18-60岁），性别不限，被随机分为2 组（n=30）：对照组（C组）和硫酸镁组（T组）。T组于诱导后即予静脉注射50mg/kg硫酸镁，C组予生理盐水。术前、术后检测血镁浓度。记录术中异丙酚、瑞芬太尼的用药量，并在术后不同时间点记录疼痛、恶心呕吐、肌张力及腱反射等不良事件发生情况。 结果 术中静脉给予硫酸镁可有效减少术中异丙酚及瑞芬太尼的用量（P<0.05），并可明显降低术后疼痛（P<0.05）。而恶心呕吐、肌张力及腱反射等术后不良事件发生及术后血镁浓度无明显改变（P>0.05）。结论 术中静脉注射硫酸镁(50mg/kg)可有效减少术中异丙酚及瑞芬太尼用量，并可有效减低术后疼痛，且对术后不良事件发生无明显影响。 |
| 关键词: 硫酸镁 异丙酚 瑞芬太尼 术后不良事件 |
| DOI：10.3724/SP.J.1008.2014.00808 |
| 投稿时间：2014-01-02修订日期：2014-04-22 |
| 基金项目: |
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| Effect of intraoperative intravenous magnesium sulfate on anesthetic drugs and postoperative adverse events |
| 陈巍 |
| () |
| Abstract: |
| Objective Evaluation the effect of intraoperative intravenous magnesium sulfate on propofol , fentanyl dose and postoperative adverse events. Methods Sixty ASA I orⅡ patients of either sex，aged18-60 yrs.，undergoing craniocerebral surgery with general anesthesia were randomly divided into 2 groups(n=30 each)：control group(group C)and magnesium sulfate group(group T)．T group received intravenous 50 mg/kg magnesium sulfate after the induction, while C group received normal saline. Blood concentration of magnesium was measured before and after operation. The dose of intraoperative propofol and fentanyl, and the incidence of postoperative pain, nausea and vomiting, muscle tension and tendon reflex and other adverse events at different time were recorded. Results Intraoperative intravenous magnesium sulfate can effectively reduce the intraoperative propofol and fentanyl dosage（P<0.05）, and alleviate postoperation pain（P<0.05）. While, there was no obvious change in adverse events, such as Nausea and vomiting, muscle tension and tendon reflex, and postoperative blood concentration of magnesium（P>0.05）. Conclusion Intraoperative intravenous magnesium sulfate (50 mg/kg) can effectively reduce the intraoperative propofol and fentanyl dosage, and can effectively alleviate postoperative pain, while had no obvious effect on postoperative adverse events. |
| Key words: magnesium sulfate propofol fentanyl postoperative adverse event |
