| 摘要: |
| 在治疗前列腺癌的各种传统方法中,普遍存在着杀伤癌细胞的同时对正常组织器官造成损伤的现象。近年来兴起的靶向治疗在一定程度上能很好地解决这一问题。但作为靶向治疗的载体,病毒类载体存在免疫原性大、毒性大等缺点,而非病毒类载体靶向治疗前列腺癌往往能克服这些缺点。本文综述了以阳离子聚合物、脂质体和壳聚糖聚合物为主的非病毒类载体包裹基因药物靶向治疗前列腺癌的研究进展。 |
| 关键词: 前列腺肿瘤 靶向治疗 非病毒类载体 基因药物 |
| DOI：10.3724/SP.J.1008.2015.00888 |
| 投稿时间：2015-04-14修订日期：2015-05-19 |
| 基金项目:国家自然科学基金(81372762,81302212). |
|
| Non-viral vectors for targeted therapy of prostate cancer: recent advance |
| YAO Chong1,WU Xin1,2,ZHANG Li-juan1,GAO Shen1* |
(1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Pharmaceutics, The First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai 200080, China
*Corresponding author) |
| Abstract: |
| The current therapies for treating prostate cancer, in many cases, also cause damage to normal tissues and organs at the same time when killing cancer cells. The recent development of targeted therapy to some extent, may be a good solution to this problem. As vectors in targeted therapy, viral vectors have strong immunogenicity, toxicity and other disadvantages, and non-viral vectors for targeted therapy of prostate cancer may overcome these drawbacks. This review summarized the recent application of cationic polymers, liposomes and polymeric chitosan as non-viral vectors of gene drug for targeted therapy of prostate cancer. |
| Key words: prostatic neoplasms targeted therapy non-viral vectors gene drug |
