| 摘要: |
| 目的 探讨血清脑源性神经营养因子(BDNF)、血清血管内皮生长因子(VEGF)与2型糖尿病(T2DM)颈动脉粥样硬化的关系。方法 收集兰州大学第二医院糖尿病2科住院T2DM患者120例,依据颈动脉彩色多普勒超声显像分为合并颈动脉粥样硬化组64例(C组)和非颈动脉粥样硬化组56例(B组)。另收集同期体检中心健康体检者60例为健康对照组(A组)。收集临床资料,并使用ELISA方法测定血清BDNF 、VEGF浓度。结果 A组、B组、C组血清BDNF[(9.97±2.59)、(6.88±3.10)、(5.62±3.41)ng/ml]水平逐渐降低,差异具有统计学意义(P＜0.05)；各组血清VEGF[(49.29±20.23)、(61.29±22.05)、(71.34±20.30)pg/ml]水平逐渐升高,差异具有统计学意义(P＜0.05)。结论 T2DM合并颈动脉粥样硬化患者血清BDNF水平降低、VEGF水平升高,提示血清低浓度BDNF及高浓度VEGF共同参与颈动脉粥样硬化的发生及发展。 |
| 关键词: 2型糖尿病 颈动脉粥样硬化 脑源性神经营养因子 内皮细胞生长因子 |
| DOI：10.3724/SP.J.1008.2014.00920 |
| 投稿时间：2014-04-17修订日期：2014-06-17 |
| 基金项目: |
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| Relationship of the serum level of BDNF and VEGF with the carotid atherosclerosis in type 2 diabetes mellitus |
| qiushichao,renjiangong,罗晖,huxuejian,houyuanhua |
| (Lanzhou University;Lanzhou University Second Hospital) |
| Abstract: |
| 【】Objective To investigate the relationship between brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor(VEGF)with the carotid atherosclerosis in type 2 diabetes mellitus(T2DM). Methods A total of 120 T2DM patients were assigned to non carotid atherosclerosis group( group B, n=56) and the carotid atherosclerosis group( group C,n=64) bycarotid artery ultrasound detection. 60 healthy controls were recruited from health check-up populations(group A).Clinical data was collected,SandSthe level of BDNF,SVEGF were determined by ELISAS.Results The level of BDNF (9.97±2.59),(6.88±3.10),(5.62±3.41)ng/ml of group A, group B, group C was gradually decreased (P＜0.05); The level of VEGF (49.29±20.23), (61.29±22.05),(71.34±20.30)pg/ml of the there groups was gradually increased (P＜0.05).Conclusions The level of BDNF is significantly decreased and the VEGF is significantly increased in T2DM with carotid atherosclerosis, suggesting that low level of BDNF and high level of VEGF are correlated with the occurrence and development of carotid atherosclerosis. |
| Key words: type 2 diabetes mellitus carotid atherosclerosis brain derivedSneurotrophic factor vascular endothelial growth factor |
