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| 肥胖患者头部脂肪与代谢的相关性 |
| 王兴纯1,刘欢2,黄玥晔1,孙航1,卜乐1,曲伸1* |
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(1. 同济大学附属上海市第十人民医院内分泌代谢科, 上海 200072;
2. 镇江市第一人民医院泌尿外科, 镇江 212002
*通信作者) |
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| 摘要: |
| 目的 探讨肥胖患者头部脂肪含量与代谢指标间的关系。 方法 收集2011年9月至2014年12月于上海市第十人民医院门诊就诊、以双能X线(DEXA)测定的99例肥胖患者资料,同时采集他们的体质量、体质指数(BMI)、颈围、腰围、臀围、内脏脂肪指数、基础代谢、肝功能及空腹血糖、空腹胰岛素、空腹C肽、血脂、尿酸、C-反应蛋白进行分析。 结果 (1)99例患者中男性35例,女性64例。平均头颈部脂肪(1.67±0.34) kg。(2)男性和女性患者头部脂肪与体质量、BMI、颈围、腰围、臀围、内脏脂肪指数、基础代谢、头部脂肪百分比、上肢脂肪、四肢脂肪、躯干脂肪、全身总脂肪、全身总肌肉均呈正相关(男性r=0.620、0.616、0.670、0.678、0.663、0.635、0.518、0.635、0.488、0.458、0.588、0.618、0.579,女性r=0.624、0.593、0.610、0.672、0.482、0.657、0.647、0.616、0.639、0.336、0.467、0.544、0.762,均P<0.05),女性头部脂肪还与空腹胰岛素以及尿酸呈正相关(r= 0.348、0.349,均P<0.05)。总体肥胖患者中,头部脂肪与体质量、BMI、颈围、腰围、臀围、内脏脂肪指数、基础代谢、尿酸、头部脂肪百分比、上肢脂肪、四肢脂肪、躯干脂肪、全身总脂肪、全身总肌肉以及躯干/外周脂肪比值均呈正相关(r=0.664、0.598、0.685、0.716、0.575、0.703、0.610、0.288、0.526、0.542、0.346、0.527、0.564、0.688、0.207,均P<0.05)。(3)颈围及腰围是总体肥胖患者头部脂肪的预测指标(β=12.802、29.138,均P<0.05),腰围是男性头部脂肪的预测指标(β=21.108,P<0.001),总肌肉含量、上肢脂肪以及基础代谢是女性头部脂肪的预测指标(β=0.046、0.116、-0.914,均P<0.05)。 结论 肥胖患者头部脂肪与全身脂肪含量、分布及尿酸相关。头部脂肪可以作为评价肥胖患者代谢情况的指标之一。 |
| 关键词: 肥胖症 头部脂肪 脂类代谢 尿酸 |
| DOI：10.3724/SP.J.1008.2015.1242 |
| 投稿时间：2015-03-24修订日期：2015-05-15 |
| 基金项目: |
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| Correlation between head fat and metabolism in patients of obesity |
| WANG Xing-chun1,LIU Huan2,HUANG Yue-ye1,SUN Hang1,BU Le1,QU Shen1* |
(1. Department of Endocrinology and Metabolism, The Tenth People's Hospital of Shanghai, Tongji University, Shanghai 200072, China;
2. Department of Urology, Zhenjiang First People's Hospital, Zhenjiang 212002, Jiangsu, China
*Corresponding author.) |
| Abstract: |
| Objective To investigate the association between head fat and metabolic parameters in Chinese obese patients. Methods The data of 99 obese patients were collected from the outpatient department, the Tenth People's Hospital of Shanghai from September, 2011 to December, 2014. The accumulated regional fat was measured by dual-energy X-ray absorptiometry (DEXA). The body weight, body mass index (BMI), neck circumference (NC), waist circumference (WC), hip circumference (HC), visceral index, basal metabolism (BM), liver function, fasting plasma glucose (FPG), fasting insulin, fasting C peptide, blood lipid, uric acid (UA) and C-reactive protein were also obtained for analysis. Results (1) The participants consisted of 35 men and 64 women, with a mean head fat of (1.67±0.34) kg. (2) The head fat was positively correlated with body weight, BMI, NC, WC, HC, visceral index, BM, head fat percentage, arm fat, arms and legs fat, trunk fat, total fat and total muscle in both male and female participants (male: r=0.620, 0.616, 0.670, 0.678, 0.663, 0.635, 0.518, 0.635, 0.488, 0.458, 0.588, 0.618, and 0.579; female: r=0.624, 0.593, 0.610, 0.672, 0.482, 0.657, 0.647, 0.616, 0.639, 0.336, 0.467, 0.544, and 0.762, repectively; all P<0.05). In the female participants the head fat was positively correlated with fasting insulin and UA (r=0.348, 0.349,all P<0.05). For all the participants, the head fat was positively correlated with body weight, BMI, NC, WC, HC, visceral index, BM, UA, head fat percentage, upper arm fat, arms and legs fat, trunk fat, total fat, total muscle, and trunk/peripheral fat (r=0.664, 0.598, 0.685, 0.716, 0.575, 0.703, 0.610, 0.288, 0.526, 0.542, 0.346, 0.527, 0.564, 0.688, and 0.207,respectively; all P<0.05). (3) NC and WC were predictors of head fat for all subjects (β=12.802 and 29.138, both P<0.05); WC was a predictor of head fat for males (β=21.108, P<0.001); and total muscle, upper arm fat, and BM were predictors of head fat for females (β=0.046, 0.116, and-0.914, all P<0.05). Conclusion Head fat accumulation is closely related to the content and distribution of total fat and UA. Head fat may be used as an indicator for metabolic disorder risk for Chinese obese patients. |
| Key words: obesity head fat lipid metabolism uric acid |
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