| 摘要: |
| 目的 探讨代餐(益力佳SR,雅培)对肥胖患者减重及体脂分布的作用。方法 选取22例肥胖患者进行代餐膳食5周,口服益力佳6勺约52 g/次,计220.48 kcal(1 772 kJ)热量, 每晚1次,代替晚餐。治疗前后测定体质量(body mass,BM)、体质指数(BMI)、血压、体脂、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及空腹血糖和胰岛素。试验采用前后自身配对设计。结果 与代餐膳食之前相比,代餐膳食5周后肥胖患者体质量 (P<0.001)、BMI (P<0.001)、总脂肪含量 (P=0.035)、脂肪含量百分比 (P=0.033)、躯干脂肪含量 (P=0.002)均下降;而外周脂肪含量和上肢脂肪含量/下肢脂肪含量减少差异无统计学意义 (P>0.05);脂代谢方面:代餐善食5周后,肥胖患者TG下降 (P=0.028)同时HDL升高,差异有统计学意义 (P<0.001);糖代谢:胰岛素抵抗指数(HOMA-IR)有下降趋势,差异无统计学意义 (P=0.372)。结论 代餐干预可减轻肥胖患者体质量、改善肥胖患者脂肪分布,同时有效调节血脂和血糖,有利于改善肥胖患者代谢水平,并具有良好的耐受性和安全性。 |
| 关键词: 代餐 肥胖症 体脂分布 脂代谢 |
| DOI：10.3724/SP.J.1008.2015.00450 |
| 投稿时间：2014-08-26修订日期：2014-11-01 |
| 基金项目: |
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| Effects of meal replacement on weight loss and fat redistribution in simple obesity patients |
| WANG Xing-chun1,2,HUANG Yue-ye1,CAO Han1,BU Le1,QU Shen1* |
(1. Department of Endocrinology and Metabolism, Tenth People's Hospital of Shanghai, Tongji University, Shanghai 200072, China;
2. Department of Clinical Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China
*Corresponding author) |
| Abstract: |
| Objective To evaluate the effects of meal replacement (Glucerna SR, Abbort) on weight loss and fat redistribution in patients with simple obesity. Methods Twenty-two simple obesity patients received dinner replacement with Glucerna for five weeks (6 spoons, about 52 g per time, 220.48 kcal [1 772 kJ]), once a day at night replacing dinner. The weight, blood pressure, BMI, lipid, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose, and insulin were all observed before and after dinner replacement. The fat distribution was detected by DEXA (dual energy X-ray absorptiometry). The study was done by before-after design in the same patients. Results The body weight (P<0.001) and BMI (P<0.001) were significantly decreased after dinner replacement in our group. Dinner replacement also led to significant decrease of total fat mass (P=0.035), fat mass percentage (P=0.033) and trunk fat mass (P=0.002), while the decreases of peripheral fat mass and arm fat/leg fat mass were not significant. Lipid profiles showed that TG was significantly decreased (P=0.028)and HDL was significantly increased (P<0.001) after dinner replacement. Dinner replacement with Glucerna also resulted in a reduced HOMA-IR, though without statistical significance (P=0.372). Conclusion Dinner replacement can greatly reduce the weight of obese patients, improving fat distribution and regulating blood lipid and glucose. Dinner replacement is tolerable and safe, and it can improve the metabolism of obese patients. |
| Key words: meal replacement obesity body fat distribution lipid metabolism |
