| 摘要: |
| 蛋白聚糖诱导的小鼠关节炎模型(PGIA)是由人类关节软骨来源的蛋白聚糖免疫BALB/c小鼠或C3H小鼠的某些亚系而产生的系统性自身免疫性脊柱关节炎小鼠模型。该模型是目前唯一侵犯中轴骨系统的系统性自身免疫小鼠模型, 已成为脊柱关节炎动物模型的研究热点。本文旨在通过回顾国内外PGIA相关研究文献, 对普遍关注的PGIA动物模型的诱导、表型鉴定、免疫学特性及骨化相关信号通路等进行综述, 为脊柱关节炎动物模型研究提供理论基础。 |
| 关键词: 脊柱关节炎 蛋白聚糖类 动物模型 小鼠 免疫 |
| DOI：10.3724/SP.J.1008.2015.00530 |
| 投稿时间：2014-09-03修订日期：2015-03-18 |
| 基金项目: |
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| Proteoglycan-induced arthritis model in mice: research progress |
| TONG Wen-wen,LI Jia,XU Wei-dong* |
(Department of Joint and Bone Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Proteoglycan-induced arthritis (PGIA) is a unique systemic autoimmune disease model of spondyloarthritis (SpA) induced by intraperitoneal immunization of either BALB/c or certain C3H colonies with cartilage proteoglycan. This model is currently the only systemic autoimmune mice model with axial skeleton manifestation, which has become a focus of study in SpA modeling. Here in this review we summarize the methods of animal model building, phenotype identification, immunological characteristics and pathways involved in bone remodeling of PGIA based on previous studies, hoping to provide references for study on SpA animal model. |
| Key words: spondyloarthritis proteoglycans animal models mice immunity |
