| 摘要: |
| 目的 系统评价菊粉类果聚糖对致动脉粥样硬化相关3种主要血脂的影响,为动脉粥样硬化防治饮食策略的制定提供依据。方法 全面检索PubMed、Embase、中国知网、中国生物医学文献数据库、中文科技期刊数据库和万方数据知识服务平台中的相关文献,按照预先制定的纳入和排除标准筛选文献,之后进行质量评价和数据提取,最终采用Stata 11.0软件进行meta分析和发表偏倚的检测。结果 最终纳入22篇文献,总样本数为822例,实验组413例,对照组409例。Meta分析结果显示,菊粉类果聚糖对高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平影响的合并加权均数差(weighted mean difference,WMD)值及95%CI分别为0.05 (0.01,0.08) mmol/L、－0.08 (－0.14,－0.01) mmol/L、－0.16 (－0.25,－0.06) mmol/L。亚组分析结果显示:菊粉类果聚糖可 使血脂异常亚组TG水平降低0.17 mmol/L, 糖尿病亚组HDL-C水平升高0.15 mmol/L,TG水平降低0.30 mmol/L,差异有统计学意义(P<0.05)。结论 每日摄食适量菊粉类果聚糖可提升人体血清HDL-C水平,降低TG和LDL-C水平,血脂异常人群、糖尿病人群获益更多。 |
| 关键词: 菊粉类果聚糖 动脉粥样硬化 血脂异常 meta分析 |
| DOI：10.3724/SP.J.1008.2015.00287 |
| 投稿时间：2014-09-27修订日期：2015-01-30 |
| 基金项目:教育部春晖计划合作科研启动项目 (Z2012118). |
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| Effect of inulin-type fructans on atherosclerosis associated blood lipid profile: a systematic review and meta-analysis of randomized controlled trials |
| WU Shi-shi1,WANG Long2,XU Cai1,ZHOU Ling-yu1,ZHANG Yong1,LIAN Xue-mei1* |
(1. Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China;
2. Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
*Corresponding author) |
| Abstract: |
| Objective To systematically review the clinical trials examining the effects of inulin-type fructans on 3 major atherosclerosis associated blood lipid profiles, so as to provide references on dietary strategy for atherosclerosis prevention. Methods Relevant literatures were comprehensively searched in PubMed, Embase, CNKI, CBM, VIP, and Wanfang Databases. Eligible studies were selected according to the inclusion and exclusion criteria. Then the quality evaluation (JADAD scale) and data extraction were conducted. Meta-analysis and publication bias were performed using software Stata 11.0. Results Twenty-two studies were finally included in this study, involving a total of 822 cases, with 413 in the treatment group and 409 in the control group. The results of the meta-analysis showed that the pooled WMD (95% confidence interval) of inulin-type frutans' effect on HDL-C, TG, and LDL-C were 0.05 (0.01,0.08) mmol/L, -0.08 (－0.14,－0.01) mmol/L and -0.16 (－0.25,－0.06) mmol/L, respectively. Subgroup analysis results revealed that TG level decreased dramatically by 0.17 mmol/L in the dyslipidemia group (P<0.05). In the diabetes group, a noticeable increment of 0.15 mmol/L was found for HDL-C and a reduction of 0.30 mmol/L was found for TG (P<0.05). In addition, no significant changes were found for other parameters of the blood lipids. Conclusion Daily intake of proper amount of inulin-type fructans can increase serum HDL-C level and decrease TG and LDL-C levels, which is especially beneficial for dyslipidemia and diabetic patients. |
| Key words: inulin-type fructans atherosclerosis dyslipidemias meta-analysis |
