| 摘要: |
| 目的 探讨激光辅助孵化(laser-assisted hatching,LAH)对种植失败患者冻融胚胎移植(frozen-thawed embryo transfer,FET)周期妊娠结局的影响。 方法 2012年5月至2013年12月在本中心接受辅助生殖治疗的97例胚胎种植失败患者,选取其124个FET周期并随机分为两组:孵化组(61个周期),胚胎移植前行LAH;未孵化组(63个周期),胚胎移植前未行辅助孵化。比较两组的临床妊娠率和胚胎种植率以及流产率、多胎率。 结果 孵化组的临床妊娠率(47.5%)、胚胎种植率(29.2%)均高于未孵化组(30.2% 和 19.0%),差异有统计学意义 (P<0.05)。流产率、多胎率等结局指标在两组间的差异无统计学意义(P>0.05)。 结论 LAH可明显提高种植失败患者FET周期临床妊娠率和胚胎种植率,改善临床结局。 |
| 关键词: 冻融胚胎移植 激光辅助孵化 种植失败 妊娠结局 |
| DOI：10.16781/j.0258-879x.2016.01.0106 |
| 投稿时间：2015-05-08修订日期：2015-07-29 |
| 基金项目:上海市科委产学研重点专项(14DZ1942502). |
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| Effect of laser-assisted hatching on outcome of frozen-thawed embryo transfer for patients with previous repeated implantation failure |
| LU Xin-mei△,XU Chen△,WANG Liang,SUN Ning-xia,ZHANG Qing,GUAN Peng-fang,LI Wen* |
(Reproductive Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
△Co-first authors.
*Corresponding author.) |
| Abstract: |
| Objective To determine whether laser-assisted hatching (LAH) can improve the clinical outcome of frozen-thawed embryo transfers (FET) for patients with previous repeated implantation failure. Methods A total of 97 infertility patients with previous repeated failure, who received assisted reproductive therapy in our in-vitro fertilization(IVF) center from May 2012 to December 2013, were included in this study. A total of 124 FET cycles were randomly divided into LAH group (LAH was performed before embryo transplantation, n=61) and non-assisted hatching group (LAH was not performed before embryo transplantation, n=63). The clinical pregnancy rate,implantation rate, abortion rate and multiple pregnancy rate were compared between the two groups. Results The pregnancy rate (47.5% vs 30.2%,P<0.05) and implantation rate (29.2% vs 19.0%,P<0.05) in the assisted hatching group were both significantly higher than those in the non-assisted hatching group.There were no significant differences between the two groups in abortion rate or multiple pregnancy rate(P>0.05). Conclusion The LAH can increase the pregnancy and implantation rates and improve the outcome of IVF-ET in frozen-thawed embryo transfer cycles for patients with previous repeated failure. |
| Key words: frozen-thawed embryo transfers laser-assisted hatching implantation failure pregnancy outcome |
