| 摘要: |
| 目的 探讨中老年人群血清HER-2水平与代谢综合征的关联性。方法 研究人群为崇明城桥社区687名中老年人群, 其中男性309例, 女性378例。血清HER-2水平采用ELISA方法检测。代谢综合征定义依据NCEP ATPⅢ(National Cholesterol Education Program Adult Treatment Panel Ⅲ, NECP ATPⅢ)亚裔美国人标准。结果 在校正相关影响因素后, 代谢综合征(+)组(n=370)血清HER-2水平高于对照组(n=317)[(12.4±2.3) ng/mL vs (8.2±1.6) ng/mL, P<0.001]。随着代谢综合征组分累加, 血清HER-2水平增加(P<0.001)。校正其他风险因素后, 多元logistic回归分析显示第4四分位数血清HER-2值组其代谢综合征发生风险较第1四分位数组增加, 其OR值为1.35(95% CI: 1.14~2.31, P<0.001)。结论 在中老年人群中血清HER-2水平与代谢综合征发病风险相关, 且这种关联性独立于其他代谢综合征的风险因素。 |
| 关键词: 原癌基因 HER-2 代谢综合征 中年人 老年人 |
| DOI：10.3724/SP.J.1008.2015.00518 |
| 投稿时间：2014-11-06修订日期：2015-02-06 |
| 基金项目: |
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| Association of serum HER-2 level with metabolic syndrome in middle-aged and elderly population |
| QIN Li*,ZHU Ling-fei,LU Shuai |
(Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiaotong University School of Medicine, Shanghai 202150, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the association of circulating HER-2 level with metabolic syndrome in middle-aged and elderly population. Methods We conducted a population-based cross-sectional study with 687 participants aged 40 years or older from a community in Chongming District, Shanghai, China. Serum HER-2 levels were measured using ELISA. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP ATP Ⅲ) criteria for Asian-Americans. Results After adjusting for other influencing factors, we found that the participants with metabolic syndrome (n=370) had significantly higher HER-2 level compared with the control group (n=317) ([12.4±2.3] ng/mL vs [8.2±1.6] ng/mL, P<0.001). The serum HER-2 level increased (P<0.001) with the accumulation of the metabolic syndrome components. After adjusting for potential risk factors, multiple logistic regression analysis showed that the highest quartile of serum HER-2 was associated with increased risk of metabolic syndrome, with a fully adjusted odds ratio (OR) of 1.35 (95% confidence interval [CI]: 1.14-2.31), P<0.001). Conclusion Serum HER-2 is independently associated with metabolic syndrome in middle-aged and elderly Chinese in this study. |
| Key words: proto-oncogenes HER-2 metabolic syndrome middle aged aged |
