| 摘要: |
| 目的 采用包合技术提高黄芩素的溶解度及溶出速率, 进而考察渗透泵片片芯及包衣处方对黄芩素包合物单层渗透泵片体外释药行为的影响, 并优化最佳处方。方法 利用包合技术制备黄芩素包合物, 并测定其溶解度及溶出速率。以累积释放度为评价指标, 通过单因素考察NaCl用量、聚氧乙烯 (PEO)用量、包衣增重及增塑剂用量对释药行为的影响, 并采用正交试验得到黄芩素包合物单层渗透泵片最佳处方。结果 将黄芩素制备成包合物后, 溶解度及溶出速率得到显著提高。正交试验结果显示, 渗透泵片片芯处方中PEO用量和包衣膜处方中增塑剂聚乙二醇(PEG)400用量对释药行为有较大影响, 得到的最佳处方为:黄芩素包合物180 mg, NaCl用量100 mg, PEO用量80 mg, 包衣增重4%, 增塑剂用量为9%。优化后的黄芩素包合物渗透泵片在12 h内呈现良好的零级释放(r=0.997 8), 药物释放比较完全(>88%)。结论 以环糊精包合物为中间体成功制备了黄芩素单层渗透泵片, 其释药行为符合零级动力学方程。 |
| 关键词: 黄芩素 包合物 单层渗透泵片 制药工艺学 |
| DOI：10.3724/SP.J.1008.2015.00513 |
| 投稿时间：2014-11-18修订日期：2014-12-26 |
| 基金项目: |
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| Preparation technique of monolithic osmotic pump tablet containing inclusion complex of baicalein |
| DENG Xiang-tao1*,HAO Hai-jun2,HAN Ru2,JIA You-zhi2 |
(1. Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China;
2. Instrumental Analysis & Research Center, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China
*Corresponding author) |
| Abstract: |
| Objective To use the inclusion technology for improving the solubility and dissolution rate of baicalein from monolithic osmotic pump tablet containing inclusion complex of baicalein by observing the effects of the core and coating on in vitro drug release. Methods Baicalein-inclusion complex was prepared by the inclusion technique, and its solubility and dissolution rate were determined. The percent of cumulative release was used to evaluate the drug release profile in vitro. Single factor analysis was used to study the effects of NaCl and PEO amounts, coating weight and plasticizer amount on drug release. Then orthogonal design was used to select the optimal formulation of monolithic osmotic pump tablet containing baicalein-inclusion complex. Results The solubility and dissolution rate of baicalein were greatly enhanced when prepared into inclusion complex. Orthogonal design results indicated that PEO content in the tablet core and plasticizer PEG 400 in the coating had significant effects on the drug release, and the optimum formulation was: baicalein-inclusion complex 180 mg, NaCl 100 mg, PEO 80 mg, coating weight 4% and plasticizer 9%. The tablets with optimized formula achieved the desired zero-order release profile (r=0.997 8) within 12 hours and the cumulative release was higher than 88%. Conclusion Monolithic osmotic pump tablet of baicalein has been successfully prepared using inclusion complex as the intermediate, and the release behavior accords with zero-order kinetics equation. |
| Key words: baicalein inclusion complex monolithic osmotic pump tablet pharmaceutical technology |
