| 摘要: |
| 目的 探讨老年弥漫性大B细胞淋巴瘤(DLBCL)患者发生静脉血栓栓塞(VTE)的影响因素。方法 选取我院2003年6月至2013年10月收治的142例老年DLBCL患者作为观察对象,分析性别、体质指数(BMI)、体能评分(ECOG-PS)、肿瘤分期、乳酸脱氢酶水平(LDH)、高血压、糖尿病、血红蛋白水平、白细胞、血小板计数等因素与VTE发生的关系,并分析目前血栓治疗措施的疗效。结果 单因素logistic回归分析结果显示:PS评分≥2(P=0.027)、国际淋巴瘤预后指数(IPI)积分=3~4分(P=0.051)、3~4个疗程化疗未达到完全缓解(non-CR, P=0.016)是影响老年DLBCL患者血栓形成的危险因素;多因素回归分析显示:PS评分≥2、3~4个疗程化疗non-CR是影响血栓形成的独立危险因素(P < 0.05)。结论 PS评分≥2、3~4个疗程化疗 non-CR 是影响老年DLBCL患者血栓形成的独立危险因素。 |
| 关键词: 老年人 弥漫性大B细胞淋巴瘤 静脉血栓形成 |
| DOI：10.3724/SP.J.1008.2015.00342 |
| 投稿时间：2014-08-18修订日期：2015-01-04 |
| 基金项目:国家自然科学基金(81172249). |
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| Risk factors of venous thrombosis in elderly patients with diffuse large B-cell lymphoma |
| LIU Jin,YANG Jian-min* |
(Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To analyze the risk factors of venous thromboembolism (VTE) in elderly patients with diffuse large B-cell lymphoma (DLBCL). Methods A total of 142 elderly DLBCL patients who were treated in our hospital from Jun. 2003 to Oct. 2013 were included in the present study. The relationship of VTE with gender, body mass index (BMI), physical score (ECOG-PS), tumor stage, lactate dehydrogenase level, hypertension, diabetes, hemoglobin level, white blood cell count, and platelet count were analyzed. The efficacy of current treatment of thrombosis was also analyzed. Results Univariate analysis showed that PS score≥2 (P=0.027), IPI points=3-4 (P=0.051), and non-CR after 3-4 cycles of chemotherapy (P=0.016) were risk factors for thrombosis in elderly DLBCL patients; multivariate analysis displayed that PS score≥2 and non-CR after 3-4 cycles of chemotherapy were independent risk factors for thrombosis (P<0.05). Conclusion PS score ≥2 and non-CR after 3-4 cycles of chemotherapy are the independent risk factors for thrombosis in elderly DLBCL patients. |
| Key words: aged diffuse large B-cell lymphoma venous thrombosis |
