| 摘要: |
| 纳米磁性对比剂已成为MRI对比剂研究的重要方向, 其独特的理化性质及生物学特性展示出良好的应用前景, 并在临床诊断及科研工作中发挥着日益重要的作用。纳米磁性对比剂具有特殊的理化及生物学特性, 容易被体内组织中巨噬细胞所吞噬, 进而引起相关病灶部位MRI信号强度的变化, 利于进行疾病的定量分析, 具有广阔的应用前景。因此, 本文就纳米磁性对比剂在巨噬细胞相关疾病MRI成像中的应用研究进行综述。 |
| 关键词: 磁性纳米材料 巨噬细胞 对比剂 磁共振成像 |
| DOI：10.3724/SP.J.1008.2015.00536 |
| 投稿时间：2014-12-30修订日期：2015-03-02 |
| 基金项目:国家自然科学基金(81270413). |
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| Current research on application of nano-magnetic contrast agent in MR imaging for macrophage in human diseases |
| DONG Yin-mei,CHEN Huai-wen,LIU Qi* |
(Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Nano-magnetic contrast agent has become one of the important research directions of MRI contrast agent; its unique physical and chemical properties and biological characteristics present a promising application prospect and play an increasingly important role in clinical and research work. Nano-magnetic contrast agent with special physicochemical and biological properties could be swallowed by human macrophages easily, causing changes of MRI signal intensity in lesion and possessing application prospect for quantitative diagnosis. This review discusses the recent progress on nano-magnetic contrast agent and their applications for imaging macrophages in human diseases. |
| Key words: magnetic nanomaterials macrophages contrast agent magnetic resonance imaging |
