| 摘要: |
| 目的 观察并对比乳酸左氧氟沙星/头孢唑肟在急性水肿型胆源性胰腺炎治疗中的效果,为急性胰腺炎的临床规范抗感染治疗提供参考. 方法 选取2014年1月至2014年11月期间在本院急诊科病区连续收治的180例急性水肿型胆源性胰腺炎患者,随机分为乳酸左氧氟沙星治疗组与头孢唑肟治疗组,在禁食水、胃肠减压、抑酸、抑酶、营养支持等常规治疗基础上分别选用乳酸左氧氟沙星及头孢唑肟抗感染,监测患者呕吐、腹痛、腹胀缓解情况及时间,开放饮食时间,住院天数,血常规、C反应蛋白(CRP)、生化、血清淀粉酶变化及影像学胰腺炎症吸收情况. 结果 乳酸左氧氟沙星治疗组总有效率高于头孢唑肟治疗组(P <0.05);与头孢唑肟治疗组比较,乳酸左氧氟沙星治疗组呕吐、腹痛、腹胀缓解时间缩短(P <0.01),开放饮食时间提前,住院天数缩短(P <0.05),血常规、CRP及血淀粉酶恢复正常时间均提前(P <0.05),影像学胰腺炎症吸收快(P <0.05). 结论 在急性水肿型胆源性胰腺炎抗感染治疗中,乳酸左氧氟沙星效果优于头孢唑肟. |
| 关键词: 急性胰腺炎 乳酸左氧氟沙星 头孢唑肟 治疗结果 |
| DOI：10.3724/SP.J.1008.2015.00786 |
| 投稿时间：2015-01-17修订日期：2015-03-31 |
| 基金项目: |
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| Levofloxacin lactate and ceftizoxime for anti-infective therapy of acute edematous biliary pancreatitis: a comparison of efficacy |
| LIU Tao,KANG Zhou-jun,WANG Mei-tang,HE Jian* |
(Department of Emergency, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To compare the anti-infective effects of levofloxacin lactate and ceftizoxime in treatment of acute edema biliary pancreatitis, so as to provide reference for clinical anti-infective therapy of acute pancreatitis. Methods A total of 180 consecutive patients with acute edema biliary pancreatitis, who were treated in the emergency department of Changhai Hospital from January 2014 to November 2014, were selected in the present study, and they were randomly divided into levofloxacin lactate treatment group and ceftizoxime treatment group. In addition to conventional treatment including water fasting, gastrointestinal decompression, acid suppression, enzyme suppression and nutrition support, etc., levofloxacin lactate therapy and ceftizoxime were given separately to control the infection in the two groups. Then the following parameters were observed: remission of vomiting, abdominal pain and bloating, open eating time, hospital stays, blood routine and biochemistry test, C reaction protein (CRP), serum amylase, and the absorption of inflammation of the pancreas in imaging. Results The levofloxacin lactate treatment group had a significantly higher effective rate than the ceftizoxime treatment group (P <0.05). Compared with the ceftizoxime treatment group, the remission of vomiting and abdominal pain and bloating was significantly faster in the levofloxacin lactate treatment group (P <0.01); the open eating time, hospital stays hemogram and blood amylase recovery were also significantly improved in the levofloxacin lactate treatment group (P <0.05); and the absorption of inflammation of the pancreas in CT imaging was significantly faster (P <0.05). Conclusion The study shows that levofloxacin lactate is more effective than ceftizoxime in the anti-infective therapy of acute edema biliary pancreatitis. |
| Key words: acute pancreatitis levofloxacin lactate ceftizoxime treatment outcome |
