| 摘要: |
| 心房颤动（房颤）是临床常见的心律失常，房颤易自发由阵发性向持续性乃至永久性发展，即房颤自稳现象，而心房电重构是房颤自稳过程中具有代表性的心房电生理改变。小电导钙激活钾通道（small conductance Ca2+-activated K+ channels，SK通道）是近年发现的广泛分布于心肌细胞中的离子通道，具有对胞内钙离子高敏感性的特点。SK通道在心房肌细胞的电重构中具有重要作用，尤其在促进房颤自稳并致使房颤持久化的机制中扮演了重要角色。本文旨在通过综述近年相关研究，总结SK通道促房颤自稳性的机制及相应的干预措施，并结合临床实际进行讨论。 |
| 关键词: 小电导钙激活钾通道 心房颤动 心房电重构 持续性心房颤动 |
| DOI：10.16781/j.0258-879x.2017.03.0355 |
| 投稿时间：2016-09-23修订日期：2016-12-15 |
| 基金项目:上海市申康医院发展中心新兴前沿技术联合攻关项目（SHDC12014107）. |
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| Role of small conductance Ca2+-activated K+ channels in atrial electrical remodeling and atrial fibrillation self-stabilization: a review of mechanisms |
| WANG An-li,YIN Liang,WANG Zhi-nong* |
(Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Atrial fibrillation (AF) is one of the most common types of arrhythmia in clinical practice. AF is prone to be permanent or even permanent AF from paroxysmal AF, which was called AF self-stabilization. Atrial electrical remodeling (AER) is a typical change of atrial electrophysiology in the AF self-stabilization process. Small conductance Ca2+-activated K+ channel (SK channel) is recently found and widely distributed in cardiac myocytes, and it is highly sensitive to Ca2+. Researches have shown that SK channels may affect AF self-stabilization through influencing the process of AER directly. This review aimed at summarizing the mechanisms of SK channels in the AF self-stabilization progress and the related intervention measures and discussing the role of SK channels in clinical practice. |
| Key words: small-conductance calcium-activated potassium channels atrial fibrillation atrial electrical remodeling persistent atrial fibrillation |
