| 摘要: |
| 目的 调查全民食盐加碘前后近20年第二军医大学长海医院甲状腺癌住院构成比的变化,探讨碘摄入和甲状腺癌发病之间的关系。方法 对食盐碘化前后长海医院近20年收治的甲状腺疾病患者资料进行统计分析,计算每年的甲状腺癌构成比。依据年份将患者分为4组:1993-1997年间收治甲状腺疾病患者(A组),1998-2002年间收治甲状腺疾病患者(B组),2003-2007年间收治甲状腺疾病患者(C组),2008-2012年间收治甲状腺疾病患者(D组),比较各组间甲状腺癌构成比。结果 1994年立法全民补碘后,甲状腺癌构成比自1993年的11.36%(25/220)降至7.59%(18/237),但其后又逐渐增高,2012年时已达20.76%(318/1 532)。A、B、C、D组甲状腺癌的构成比分别为8.01%(112/1 398)、9.61%(241/2 508)、11.65%(501/4 299)、16.57%(1 101/6 645)。其中 A、B(食盐碘化初期)年度段差异无统计学意义(P=0.095),而C、D(长期食盐碘化)年度段较A或B均有所增加(P<0.001)。结论 短期补碘对甲状腺癌的发病可能有一定的抑制作用。补碘10年后甲状腺癌检出率明显增高,长期碘盐的摄入也许是原因之一。 |
| 关键词: 甲状腺肿瘤 食盐加碘 构成比 |
| DOI：10.16781/j.0258-879x.2016.02.0242 |
| 投稿时间：2015-05-25修订日期：2015-08-16 |
| 基金项目: |
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| Changes of hospitalized thyroid cancer patients in a hospital during 20 years of universal salt iodization in China |
| ZHANG Wen1,HU Wei2* |
(1. Department of General Surgery, Traffic Hospital of Qinghai Province, Xining 810008, Qinghai, China;
2. Department of Thyroid and Breast Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the constituent changes of hospitalized thyroid cancer patients in Changhai Hospital(Shanghai, China) during nearly 20 years of universal salt iodization (USI), so as to understand the relationship between iodine intake and thyroid carcinoma. Methods We analyzed the patients with thyroid diseases in Changhai Hospital over the past 20 years before and after the adaptation of USI, and the annual constituent ratios of thyroid carcinoma were calculated. The patients with thyroid diseases were divided into four groups according to the years they were treated: 1993-1997 (group A), 1998-2002 (group B), 2003-2007 (group C), and 2008-2012 (group D). The constituent ratios of thyroid carcinoma were compared between different groups. Results After the adoption of universal salt iodization in 1994, the constituent ratio of thyroid carcinoma decreased from 11.36%(25/220) in 1993 to 7.59%(18/237), and then the ratio gradually increased again, reaching 20.76%(318/1 532) in 2012. The constituent ratios of thyroid carcinoma in group A, B, C and D were 8.01%(112/1 398), 9.61%(241/2 508), 11.65%(501/4 299) and 16.57%(1 101/6 645), respectively. The constituent ratios of thyroid cancer in A, B groups (initial salt iodization period) were not significantly different (P=0.095); while those in C, D groups (after long-term salt iodization) were increased significantly compared with those in A, B groups(P<0.001). Conclusion Short-term iodine supplementation may have a certain inhibitory effect against thyroid carcinoma. The detection rate of thyroid carcinoma is apparently increased 10 years after iodine supplementation; long-term iodine supplementation might be one of the reasons for the increase. |
| Key words: thyroid neoplasms salt iodization constituent ratio |
