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| 二代测序在胶质瘤研究与个体化治疗中的应用 |
| 王洪祥1,秦荣2,符达3,陈菊祥1* |
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(1. 第二军医大学长征医院神经外科, 上海市神经外科研究所, 全军神经外科研究所, 上海 200003;
2. 解放军184医院神经外科, 鹰潭 335000;
3. 中国科学院上海生物科学研究所健康科学研究所, 上海 200032
*通信作者) |
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| 摘要: |
| 脑胶质瘤是一类高度致死性恶性肿瘤，目前有关其在基因组学的研究及临床治疗存在诸多挑战。二代测序技术具有高通量优势，能通过对肿瘤全基因组、外显子组、转录组及表观遗传组全面分析加深对肿瘤基因组学的认识，并已成功应用于部分肿瘤的临床研究中，为肿瘤个体化靶向治疗提供合适可行的指导。当前，运用二代测序研究胶质瘤已成为热点，将全面阐明胶质瘤致病机制，并为制定个体化治疗方案提供策略，使患者获益。 |
| 关键词: 脑肿瘤 胶质瘤 DNA序列分析 个体化治疗 |
| DOI：10.16781/j.0258-879x.2017.08.1046 |
| 投稿时间：2016-12-20修订日期：2017-05-14 |
| 基金项目:国家自然科学基金（81272781），上海市卫生系统优秀学科带头人新百人计划（XBR02011030），上海市曙光学者计划（11SG37）. |
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| Application of next-generation sequencing in research and personalized treatment of glioma |
| WANG Hong-xiang1,QIN Rong2,FU Da3,CHEN Ju-xiang1* |
(1. Department of Neurosurgery, Shanghai Institute of Neurosurgery, Neurosurgery Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
2. Department of Neurosurgery, No. 184 Hospital of PLA, Yingtan 335000, Jiangxi, China;
3. Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
*Corresponding author) |
| Abstract: |
| Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment. Next-generation sequencing (NGS) holds many advantages, and NGS can comprehensively analyze the whole genome, exome, transcriptome and epigenome to deepen the understanding of tumor genomics; and now, it has been successfully applied in the clinical study of some tumors, especially in personalized treatment for these tumors. At present, NGS has also been a hot in glioma research to clarify the pathogenesis of glioma, so as to draw up a personalized treatment method to benefit the patients. |
| Key words: brain neoplasms glioma DNA sequence analysis personalized treatment |
