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| 血-神经屏障的研究进展 |
| 陈莉1,张恩晖1,2,陈宇峰3,4,蔡国君1* |
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(1. 第二军医大学药学院药理学教研室, 上海 200433;
2. 解放军第406医院药械科, 大连 116041;
3. 第二军医大学药学院药物分析学教研室, 上海 200433;
4. 沈阳军区总医院药学部, 沈阳 110016
*通信作者) |
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| 摘要: |
| 血-神经屏障(blood-nerve barrier, BNB)是一种类似血-脑屏障(blood-brain barrier, BBB)的屏障系统,选择性地限制血液和周围神经系统之间的物质交换。BNB在神经病变中会出现通透性等方面的改变,深入了解BNB对于治疗此类疾病具有重要意义。本文从BNB的结构和功能、细胞生物学研究进展、BNB在病理情况下的改变及意义,以及BNB与药物作用之间可能存在的联系等方面作一综述。 |
| 关键词: 血-神经屏障 神经内膜 神经束膜 外周神经 微血管内皮细胞 |
| DOI：10.16781/j.0258-879x.2016.05.0608 |
| 投稿时间：2015-09-11修订日期：2015-12-13 |
| 基金项目: |
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| The blood-nerve barrier: research progress |
| CHEN Li1,ZHANG En-hui1,2,CHEN Yu-feng3,4,CAI Guo-jun1* |
(1. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2. Department of Drug and Instrument, No. 406 Hospital of PLA, Dalian 116041, Liaoning, China;
3. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
4. Department of Pharmacy, General Hospital of PLA Shenyang Military Area Command, Shenyang 110016, Liaoning, China
*Corresponding author) |
| Abstract: |
| The blood-nerve barrier (BNB) is a barrier system similar to blood-brain barrier (BBB), which can selectively limits the interchange of materials between the blood and the peripheral nervous system. It has been reported that the change of BNB permeability occurs in nerve lesions, and further research on BNB is of great significance for the treatment of those diseases. This paper mainly introduced the structure and function of BNB, progress of BNB cellular biology, changes and significance of BNB under pathological conditions, and the possible association between BNB and drug effects. |
| Key words: blood-nerve barrier endoneurium perineurium peripheral nerves microvascular endothelial cells |
