| 摘要: |
| 肠道菌群在维持人体内环境稳态方面起着至关重要的作用，其与疾病的关系越来越多地受到重视，但相关病理生理学机制还远不清楚。近期的研究证实，肠道菌群失调参与肝癌的发生和发展过程，涉及由菌群失调引起的胆汁酸代谢改变、肝星状细胞衰老、内毒素代谢紊乱等。本文就肠道菌群失调诱导的这些变化促进肝癌发生和发展的作用机制研究进展作一综述，指出靶向肠道菌群失调的肝癌预防策略和未来研究方向。 |
| 关键词: 菌群失调 肝肿瘤 脱氧胆酸 内毒素类 |
| DOI：10.16781/j.0258-879x.2016.11.1392 |
| 投稿时间：2016-03-15修订日期：2016-06-26 |
| 基金项目:国家自然科学基金（81272668）. |
|
| Gut dysbacteriosis and primary liver cancer: recent progress |
| MA Jun-yong1,YIN Zheng-feng2,SHI Le-hua1* |
(1. Department of Hepatic Surgery Ⅳ, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;
2. Molecular Oncology Laboratory, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
*Corresponding author.) |
| Abstract: |
| Gut microbiota plays important roles in maintaining human body homeostasis, and its relationship with diseases is gaining increasing attention, but the exact pathophysiological mechanisms are not fully understood. Recently, studies have shown that gut dysbacteriosis also plays a part in the development and progression of liver cancer, which involves dysbacteriosis-related changes in bile acid metabolism, hepatic stellate cell senescence, endotoxin metabolic disorders and so on. This paper reviewed the mechanisms of liver cancer involving gut dysbacteriosis, casting new lights on prevention strategies of liver cancer by targeting gut dysbacteriosis and on the future research directions. |
| Key words: gut dysbacteriosis liver neoplasms deoxycholic acid endotoxins |
