| 摘要: |
| 椎间盘退变是临床常见难题下腰痛的主要病因之一。而髓核细胞表型的改变、细胞生存时间的减少、代谢活动的降低和细胞外基质含量下降均被认为与椎间盘退变相关。椎间盘是身体内最大的无血管组织,在体内最显著的特点就是氧含量偏低。低氧诱导因子(HIF)是一种转录因子,细胞在低氧条件下诱导产生HIF从而引发一系列的细胞反应来适应低氧的外环境。HIF通过与低氧反应元件(HRE)结合以启动靶基因的转录表达。目前研究认为,HIF在椎间盘退变的病理进程中具有重要作用,可能是未来阻遏椎间盘退变进展甚至治愈这一临床难题的关键靶点。本文综述了HIF对于髓核细胞新陈代谢活动的调节作用,包括HIF在髓核细胞的表达以及HIF对于髓核细胞表型、生存、新陈代谢以及细胞外基质生成的调控。 |
| 关键词: 椎间盘退变 低氧诱导因子 髓核细胞 |
| DOI：10.16781/j.0258-879x.2016.02.0202 |
| 投稿时间：2015-10-17修订日期：2015-12-05 |
| 基金项目: |
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| Role of hypoxia-inducible factor in regulating physiological function of nucleus pulposus cells: recent progress |
| HOU Yang,SHI Jian-gang*,YUAN Wen |
(Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Intervertebral disc degeneration (IDD) is one of the main causes of low back pain-a common clinical problem. Alterations of the phenotype, reduction of survival time, decline of metabolic activity, and decrease of extracellular matrix of nucleus pulposus (NP) cells are thought associated with IDD. The intervertebral disc is the largest avascular tissue in the body, with the most distinctive characteristic being low oxygen tension. Hypoxia-inducible factor (HIF) is a transcriptional factor induced by the hypoxia condition to initiate a series of cellular responses, accommodating the hypoxia environment. HIF can start transcription of target genes by binding the hypoxia response element and may play an important role in the pathological process of IDD and serve as a crucial target for stopping progression or curing IDD. Here we summarized the roles of HIF in regulating metabolism activity of NP cells, including expression of HIF in NP cells, and regulatory roles of HIF in phenotype, survival, metabolism and extracellular matrix accumulation of NP cells. |
| Key words: intervertebral disc degeneration hypoxia-inducible factor nucleus pulposus cells |
