| 摘要: |
| 目的 用meta分析方法研究ABO血型在糖尿病患者和健康人群中的分布情况, 以评价ABO血型系统与糖尿病发生风险的关系。 方法 通过检索PubMed、中国生物医学文献数据库、维普中文科技期刊数据库、中国知网期刊数据库和万方数据库等, 收集有关糖尿病与ABO血型系统之间关系的原始文献, 按照纳入与排除标准筛选出符合要求的文献并提取出相关的数据, 使用NOS量表对纳入文献进行质量评价, 采用Review Manager 5.1和Stata 12.0软件进行meta分析。 结果 B血型和AB血型在糖尿病患者和对照人群中的分布差异有统计学意义, 表现为B血型在糖尿病患者中所占比例高于对照人群(OR=1.13, 95%CI:1.05~1.21, P=0.000 7), AB血型则在对照人群中更为常见(OR=0.86, 95%CI:0.77~0.97, P=0.01);但亚组分析时发现B血型和AB血型的分布差异仅在国外人群中有统计学意义(P<0.05)。 而A血型(OR=0.90, 95%CI:0.76~1.07, P=0.24)和O血型(OR=1.00, 95%CI:0.89~1.13, P=0.96)在两组中的分布差异无统计学意义。 结论 糖尿病的发生可能与ABO血型有关。国外人群中B血型的糖尿病发病风险高于其他血型, AB血型可能是糖尿病发生的保护因子, 而A血型和O血型在国内外人群中与糖尿病的发生均无关。 |
| 关键词: 糖尿病 ABO血型系统 meta分析 危险因素 |
| DOI：10.16781/j.0258-879x.2016.03.0309 |
| 投稿时间：2015-09-08修订日期：2015-10-27 |
| 基金项目: |
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| ABO blood group and risk of diabetes mellitus: a meta analysis |
| WEI Jie,HE Miao,WANG Long,TANG Xiao-jun* |
(Department of Epidemiology, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing 400016, China
*Corresponding author) |
| Abstract: |
| Objective To apply meta-analysis for assessing the association between ABO blood group and diabetes mellitus risk by comparing the differences of ABO blood group distribution between diabetic patients and healthy control group. Methods We searched PubMed, CBM, VIP, CNKI and Wanfang Databases to collect studies about diabetes and ABO blood group. Eligible studies were selected according to the inclusion and exclusion criteria and related data were extracted. The Newcastle-Ottawa Scale was used to assess the quality of the included studies, and meta-analysis was performed by software Review Manager 5.1 and Stata 12.0. Results Blood group B and blood group AB had a different distribution among diabetic patients and the control group. Blood group B was more frequently seen in diabetic patients (OR=1.13, 95%CI: 1.05-1.21, P=0.000 7) and blood group AB was more frequently seen in healthy control group (OR=0.86, 95%CI: 0.77-0.97, P=0.01). But only in foreign populations did subgroup analysis showed a significant difference in blood group B and blood group AB distribution among the case and control group, but not in blood group A (OR=0.90, 95%CI: 0.76-1.07, P=0.24) or the blood group O distribution (OR=1.00, 95%CI: 0.89-1.13, P=0.96). Conclusion The occurrence of diabetes mellitus may be related to ABO blood group. In foreign populations, the risk of diabetes mellitus in B blood group subjects is higher than that of other blood groups, and blood group AB may be a protective factor for diabetes. Blood group A and blood group O are not associated with diabetes in domestic or foreign populations. |
| Key words: diabetes mellitus ABO blood-group system meta-analysis risk factors |
