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NLRP3炎症小体的活化及调控机制
刘延刚,陈永春,宗英,马秀娟,陈基快,袁伯俊,陆国才*
0
(第二军医大学热带医学与公共卫生学系卫生毒理学教研室, 上海 200433
*通信作者)
摘要:
炎症小体是机体固有免疫的重要组成部分,目前对NLRP3炎症小体的研究最为热门和透彻。NLRP3炎症小体的活化因素包括病原体及其分泌的毒素、晶体和内源性危险信号等。NLRP3炎症小体的活化需要启动和激活两个步骤,其中启动机制主要针对NLRP3的转录和翻译后修饰水平,激活机制与线粒体、离子流动和溶酶体等相关。本文还综述了NLRP3炎症小体在表达、组装、活化等方面存在的负调控机制。
关键词:  NLRP3炎症小体  活化机制  负调控  固有免疫  炎症性凋亡
DOI:10.16781/j.0258-879x.2016.07.0868
投稿时间:2015-10-15修订日期:2016-02-26
基金项目:国家科技重大专项课题(2014ZX09J14106-06C,13CXZ005),国家自然科学基金(81473291,81402651,81402654),上海市自然科学基金(13ZR144940).
Activation and regulation of NLRP3 inflammasome: research progress
LIU Yan-gang,CHEN Yong-chun,ZONG Ying,MA Xiu-juan,CHEN Ji-kuai,YUAN Bo-jun,LU Guo-cai*
(Department of Health Toxicology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
* Corresponding author)
Abstract:
Inflammasome is a vital part of innate immunity, and NLRP3 inflammasome is by far the most thoroughly studied inflammasome complexes that have been described. NLRP3-activating signals include toxins secreted by pathogens, crystalline molecules and endogenous danger signals. Activation of NLRP3 inflammasome needs two steps:priming and activating. The priming step affects NLRP3 at the transcriptional and posttranscriptional modification levels; the activating step is associated with ion flowing, mitochondria and lysosomes. In this paper we also reviewed the negative regulation of NLRP3 inflammasome at the expression, assembly and activation levels.
Key words:  NLRP3 inflammasome  activation mechanism  negative regulation  innate immunity  pyroptosis