| 摘要: |
| 长链非编码RNA（long noncoding RNA，lncRNA）是一类长度大于200个核苷酸的非编码RNA，它不仅参与维持细胞的正常生理功能，而且还在肿瘤的发生、发展中发挥重要作用。越来越多的研究表明，lncRNA是判断卵巢癌患者总生存期和无病生存期的独立预测因素，并且与卵巢癌的发生、发展有密切关系。本文对lncRNA与卵巢癌的关系进行了综述，以期为卵巢癌的预防、早期诊断和治疗提供思路和方法。 |
| 关键词: 长链非编码RNA 卵巢肿瘤 生存率 无病生存 |
| DOI：10.16781/j.0258-879x.2016.10.1270 |
| 投稿时间：2016-03-30修订日期：2016-05-21 |
| 基金项目:上海市科委医学重点项目（12411950300），第二军医大学长海医院“1255”基金项目（CH125510105），上海市卫生系统重要疾病联合攻关项目（2013ZYJB0201）. |
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| Long noncoding RNAs in ovarian cancer: progress in mechanisms and the emerging landscape |
| XIA Lei-lei,ZENG Jin-feng,XU Ming-juan* |
(Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Long non-coding RNAs (lncRNAs) are a class of RNA molecules with more than 200 nucleotides that function as RNAs with little or no protein-coding capacity.They maintain the normal physiological functions of cells and are involved in the development and progression of the tumor. Growing research suggests that lncRNAs are independent prognostic factors affecting the overall survival and disease free survival of ovarian cancer and are closely related to the development and progression of tumors. This review summarized the recent progress in the relationship between lncRNAs and ovarian cancer, hoping to provide reference for the prevention, diagnosis, and therapy of ovarian cancer. |
| Key words: long non-coding RNAs ovarian heoplasms survival rate disease-free survival |
