| 摘要: |
| 随着生物技术的发展，生物大分子在疾病治疗中的作用愈加重要，如蛋白质、寡核苷酸、多肽等。但是由于细胞膜的天然屏障作用，这些生物大分子的实际应用受到限制。细胞穿膜肽（cell-penetrating peptides，CPPs）是一类具有较强细胞膜穿透能力的小分子短肽，可携带多种大分子物质进入细胞。本文综述了作为纳米载体的CPPs的分类及跨膜机制，以及近年其在抗肿瘤靶向治疗中的研究进展。 |
| 关键词: 细胞穿膜肽 肿瘤 纳米医学 靶向治疗 |
| DOI：10.16781/j.0258-879x.2017.06.0774 |
| 投稿时间：2016-11-16修订日期：2017-04-12 |
| 基金项目:国家自然科学基金（81372762，81672516，81672545） |
|
| Research progress of cell-penetrating peptides in tumor-targeted therapy |
| GONG Chun-ai,HU Chu-ling,GU Fen-fen,XIA Qing-ming,GAO Yuan,GAO Shen* |
(Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Advances in biotechnology give much importance to the therapeutic biomacromolecules in the therapy of diseases, such as proteins, oligonucleotides, and peptides. But their effects are limited in practical application because of cell membrane barrier. Cell-penetrating peptides (CPPs) are promising oligopeptides with a remarkable capacity for membrane translocation, which can carry various macromolecules into cells. In this paper, we reviewed the classification and transmembrane mechanism of CPPs as nanoparticles, with particular focus on their recent progress in tumor-targeted therapy. |
| Key words: cell penetrating peptides neoplasmas nanomedicine targeted therapy |
