| 摘要: |
| 目的 观察高压氧预处理对大鼠运动性疲劳的影响。方法 将SD大鼠置于加压氧舱进行高压氧（压力250 kPa，氧气浓度≥99%）预处理，以加压氧舱内常压空气通风处理作为对照，预处理后进行负重游泳实验。通过力竭时间及血清和骨骼肌乳酸、丙二醛、超氧化物歧化酶等指标的水平评估高压氧预处理对大鼠运动性疲劳的影响。结果 高压氧预处理后大鼠负重游泳力竭时间为（56.13±16.91）min，较常压空气组[（23.13±9.85）min]延长（P<0.01）。负重游泳20 min时，高压氧预处理组大鼠血清及骨骼肌中乳酸和丙二醛水平均较常压空气组降低（P<0.01），超氧化物歧化酶水平均较常压空气组升高（P<0.01）。结论 高压氧预处理能够显著延缓大鼠运动性疲劳的产生。 |
| 关键词: 运动性疲劳 高压氧 预处理 游泳 |
| DOI：10.16781/j.0258-879x.2016.11.1422 |
| 投稿时间：2016-04-12修订日期：2016-08-07 |
| 基金项目:第二军医大学海军医学系青年教员启动基金. |
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| Hyperbaric oxygen preconditioning delays exercise-induced fatigue in rats |
| YI Hong-jie,ZHOU Hui-peng,WANG Pin,XU Wei-gang* |
(Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Objective To investigate the effect of hyperbaric oxygen preconditioning on exercise-induced fatigue in rats. Methods SD rats were subjected to loaded swimming after hyperbaric oxygen (250 kPa, φB[O2]≥99%) pretreatment, and rats exposed to normal pressured air were set as air control group. The time to exhaustion and levels of lactic acid (LA), malondialdehyde (MDA) and superoxide dismutase (SOD) in serum and skeletal muscle were observed to assess the effect of hyperbaric oxygen preconditioning on exercise-induced fatigue in rats. Results The time to exhaustion in loaded swimming of rats in hyperbaric oxygen pretreatment group was significantly prolonged compared with that in the air control group ([56.13±16.91] min vs[23.13±9.85] min, P<0.01). After swimming for 20 min, the LA and MDA levels in the skeletal muscle and serum were significantly lower in the hyperbaric oxygen pretreatment group compared with air control group (P<0.01), while the SOD levels in skeletal muscle and serum were significantly higher compared with air control group (P<0.01). Conclusion Hyperbaric oxygen pretreatment can significantly delay the exercise-induced fatigue in rats. |
| Key words: exercise-induced fatigue hyperbaric oxygenation preconditioning swimming |
