| 摘要: |
| 目的 探讨影响脑静脉血栓形成（CVT）早期诊断的相关因素。方法 回顾性分析长海医院自2007年11月至2015年08月收治的95例CVT患者的临床资料，根据发病到确诊时间分为早期诊断组（≤7天）和延迟诊断组（>7天）。比较2组患者的基本临床资料，采用单因素和多因素Logistic回归分析影响疾病确诊的危险因素。结果 早期诊断组48例（50.5%），延迟诊断组47例（49.5%）。单因素分析显示，年龄（P=0.016）、孕产期发病（P=0.021）、血浆D-二聚体水平（P=0.004）、多发脑静脉血栓形成（P=0.010）、是否合并静脉性梗死（P=0.023）或脑出血（P=0.001）两组间比较差异有统计学意义。多因素Logistic回归分析显示，年龄（OR=4.197,95%CI=1.378~12.785；P=0.012）、血浆D-二聚体水平（OR=0.896,95%CI=0.809~0.992；P=0.034）、是否合并静脉性梗死（OR=0.093,95%CI=0.013~0.659；P=0.017）或脑出血（OR=0.167,95%CI=0.052~0.540；P=0.003）是影响CVT早期诊断的独立危险因素。结论 青年患者、血浆D-二聚体水平升高、合并脑出血或静脉性梗死是CVT早期诊断的重要条件。 |
| 关键词: 脑静脉血栓形成 早期诊断 危险因素 |
| DOI：10.16781/j.0258-879x.2016.10.1306 |
| 投稿时间：2016-04-27修订日期：2016-09-23 |
| 基金项目:上海市科委医学引导项目（124119a8900），上海申康医学发展中心临床管理优化项目（SHDC2015607）. |
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| Analysis of relative factors of cerebral venous thrombosis on early diagnosis |
| ZHOU Dan-dan,WU Tao,SHEN Lei,DENG Ben-qiang*,CHEN Lei,WANG Si-yang |
(Stroke Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Objective To analyze the relative factors in early diagnosis for cases with cerebral venous thrombosis(CVT). Methods The retrospective analysis of the clinical data in 95 patients with CVT from 2007.11to 2015.08 in Changhai Hospital was conducted. The patients were divided into early CVT diagnosis group(≤7 days) and delayed CVT diagnosis group (>7 days) according to their time from having symptoms to have a definite diagnosis．The clinical data was analyzed by univariate analysis and multivariate logistic regression analysis. Results 48 patients （50.5%）with early CVT diagnosis and 47（49.5%） with delayed CVT diagnosis. Univariate analysis showed that there was statistical significance of difference in age (P=0.016), the illness of pregnancy or puerperal (P=0.021), the level of plasma D-dimer (P=0.004), multiple CVT (P=0.010), hemorrhage (P=0.001) or venous infarction (P=0.023). Multivariate Logistic regression analysis showed that age (OR=4.197,95%CI=1.378~12.785；P=0.012), the level of plasma D-dimer （OR=0.896,95%CI=0.809~0.992；P=0.034），hemorrhage （OR=0.167,95%CI=0.052~0.540；P=0.003） or venous infarction（OR=0.093,95%CI=0.013~0.659；P=0.017）were the independent risk factors of early diagnosis. Conclusion Young patients, the increase of the level of plasma D-dimer, merged with hemorrhage or venous infarction are important conditions for the early diagnosis of CVT. |
| Key words: cerebral venous thrombosis diagnosis risk factors |
