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| 海洋生物毒素检测技术研究进展 |
| 孟文琪,裴志鹏,冯雍炜,孙铭学,鄂鹏飞,杨玉彦,赵杰,肖凯* |
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(第二军医大学热带医学与公共卫生学系防化医学教研室, 上海 200433
*通信作者) |
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| 摘要: |
| 海洋生物毒素具有分布广、毒性强及解毒难等特性，对我国公共安全和人民健康造成极大的威胁。为了保护我国的公共安全，保障人民健康，对海洋生物毒素检测的研究已经越来越多。目前，海洋生物毒素的检测方法有生物检测法、免疫分析法、液相色谱法、酶活力抑制分析法、细胞毒性试验等。本文将对海洋生物毒素检测技术的研究进展作一综述。 |
| 关键词: 海洋生物毒素 生物学鉴定法 免疫测定 液相色谱法 |
| DOI：10.16781/j.0258-879x.2016.09.1148 |
| 投稿时间：2016-05-05修订日期：2016-06-24 |
| 基金项目:国家科技新药创制重大专项（2013ZX09J13103-02C），全军后勤科研项目重大子项（AWS11C004重大子项-08），上海市卫生和计划生育委员会公共卫生建设三年行动计划，上海市卫生计生系统核生化支撑项目. |
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| Recent technique development in marine biotoxin analysis and detection |
| MENG Wen-qi,PEI Zhi-peng,FENG Yong-wei,SUN Ming-xue,E Peng-fei,YANG Yu-yan,ZHAO Jie,XIAO Kai* |
(Department of Chemical Defense Medicine, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Widespread distribution, strong toxicity, and difficulty to detoxicate make marine biotoxins a great threat to the nation's public security and health. To meet this threat, great endeavor has been devoted to marine biotoxin analysis. Up to now the methods for marine biotoxins analysis include bioassay test, immunoassay, liquid chromatography, enzyme activity assay, cytotoxicity test, etc. In this review, we summarized the major technique developments in marine biotoxins analysis. |
| Key words: marine biotoxins biological assay immunoassay liquid chromatography |
