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PD-1/PD-L1信号通路及其在肿瘤免疫治疗中的作用
王文超1,2,汪宇1,2,施乐华2,殷正丰1*
0
(1. 第二军医大学东方肝胆外科医院分子肿瘤实验室, 上海 200438;
2. 第二军医大学东方肝胆外科医院肝外四科, 上海 200438
*通信作者)
摘要:
抑制性共刺激分子程序性死亡因子1(PD-1)/程序性死亡因子配体1(PD-L1)是重要的负性免疫调节分子,在机体适应性细胞免疫中发挥着重要作用。表达PD-L1的肿瘤细胞可与T细胞表面受体分子PD-1特异性结合,从而影响T细胞的活化与分化,并抑制T细胞的抗肿瘤免疫杀伤活性。目前,已有多种靶向PD-1/PD-L1免疫检查点的药物应用于临床,并在不同类型的肿瘤治疗中显示出良好疗效。本文就PD-1/PD-L1的分子结构、表达特点、上调影响因素,以及其在促进肿瘤生长、免疫逃逸、肿瘤免疫治疗中的作用等方面的研究进展作一综述。
关键词:  程序性死亡因子1  程序性死亡因子配体1  肿瘤  免疫疗法
DOI:10.16781/j.0258-879x.2017.09.1190
投稿时间:2017-02-12修订日期:2017-05-08
基金项目:国家自然科学基金(81272668,81272669).
Programmed death 1/programmed death ligand 1 signaling pathway in tumor immunotherapy:an update
WANG Wen-chao1,2,WANG Yu1,2,SHI Le-hua2,YIN Zheng-feng1*
(1. Molecular Oncology Laboratory, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;
2. Department of Hepatic Surgery(Ⅳ), Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
*Corresponding author)
Abstract:
As negative immune regulatory molecules, the inhibitory co-stimulatory molecules programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) play important roles in the adaptive cellular immunity. PD-L1 expressed in tumor cells is involved in regulating T cell activation and differentiation and inhibiting the anti-tumor immune activity of T cell through specific binding with the receptor molecule PD-1 on T cells. Currently, a variety of agents targeting the immune checkpoints of PD-1/PD-L1 have been used in clinic, which have exhibited long-lasting effect in treatment for different types of tumors. In this review, we summed up the molecular structure, expression features, factors influencing upregulation of PD-1/PD-L1, and their roles in promoting tumor growth and escaping from immune system and tumor immunotherapy.
Key words:  programmed death 1  programmed death ligand 1  neoplasms  immunotherapy