| 摘要: |
| 5-羟色胺（5-hydroxytryptamine，5-HT）受体广泛分布于中枢和外周神经系统，参与机体多种生理功能的调控。5-HT及其类似物通过与不同亚型、不同部位的5-HT受体结合，对疼痛信号产生抑制或易化作用。在中枢神经系统，下行的5-HT能神经元能够激活抑制性中间神经元而发挥镇痛作用，且镇痛作用的强弱与5-HT能神经元的受体类型和分布密度有关。在外周，5-HT受体能够参与疼痛信号的传导，与痛觉过敏密切相关。本文主要综述了中枢和外周不同亚型5-HT受体在不同部位对疼痛信号的调控作用，为急慢性疼痛治疗与康复的基础理论研究和作用靶点选择提供参考。 |
| 关键词: 5-羟色胺 5-羟色胺受体 疼痛 脊髓 |
| DOI：10.16781/j.0258-879x.2016.12.1517 |
| 投稿时间：2016-08-09修订日期：2016-11-25 |
| 基金项目:国家自然科学基金（30901403）. |
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| 5-hydroxytryptamine receptor and its role in pain regulation: research progress |
| KONG Er-liang,WU Fei-xiang,YU Wei-feng* |
(Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
* Corresponding author) |
| Abstract: |
| 5-hydroxytryptamine (5-HT) receptors are widely distributed in the central and peripheral nervous systems, regulating and controlling various physiologic functions. 5-HT and its analogues can play both inhibitory or promoting roles in the pain signal conduction via interacting with various subtypes of 5-HT receptor at different locations. In the central nervous system, the descending serotonergic neurons exert analgesic effect by activating the inhibitory interneurons, and the analgesic efficiency depends on the quantity and subtype of the 5-HT receptors. In periphery, 5-HT receptors are involved in pain signal conduction and have a close relationship with hyperalgesia. In this review, we focused on the different subtypes of 5-HT receptors locating in the central and peripheral nervous systems, and summarized the regulation mechanisms of 5-HT receptors in the pain signal, hoping to provide a theoretical basis and new target for the therapy and recovery of acute and chronic pain. |
| Key words: 5-hydroxytryptamine 5-hydroxytryptamine receptors pain spinal cord |
