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| 嵌段共聚物胶束形态的影响因素 |
| 徐敏1,陈鸿铭1,2,邹豪1,高静1,3* |
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(1. 第二军医大学药学院药剂学教研室, 上海 200433;
2. 解放军69337部队卫生队, 塔城 834600;
3. 军事医学科学院毒物药物研究所药剂教研室, 北京 100850
*通信作者) |
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| 摘要: |
| 嵌段共聚物胶束作为一种有效的药物递送系统受到广泛关注，其具备增加疏水性药物溶解度、延长药物体内循环时间、提高药物稳定性、增强药物治疗效果等优点。胶束的形态可引起其载药和体内分布、药动学行为等性质的重大变化。本文通过对国内外文献的研读，重点探讨了影响嵌段聚合物胶束形态的重要因素（聚合物、制备因素、药物及其他），为今后该类型给药系统的设计提供参考。 |
| 关键词: 嵌段共聚物 胶束 形态 药物载体 |
| DOI：10.16781/j.0258-879x.2017.03.0360 |
| 投稿时间：2016-09-12修订日期：2016-12-19 |
| 基金项目:国家"重大新药创制"专项（2013ZX09J13109-04B）. |
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| Factors affecting the morphology of block copolymer micelles |
| XU Min1,CHEN Hong-ming1,2,ZOU Hao1,GAO Jing1,3* |
(1. Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2. Medical Team of No. 69337 Troop of PLA, Tacheng 834600, Xinjiang Uygur Autonomous Region, China;
3. Department of Pharmaceutics, Institute of Pharmacology and Toxicology of AMMS, Beijing 100850, China
*Corresponding author) |
| Abstract: |
| Block copolymer micelle has attracted great attention as an effective drug delivery system. It has many merits, such as increasing the solubility of hydrophobic drug, prolonging the in vivo drug circulation time, improving drug stability and enhancing the therapeutic effect of anticancer agents. Micelle morphology plays an important role in its drug loading, in vivo distribution and pharmacokinetic behavior. Here in this paper we provided a review of the critical factors affecting the morphology of block copolymer micelles (polymer, preparation factors, drug and others) for future reference. |
| Key words: block copolymers micelle morphology drug carriers |
