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富氢水抗炎活性及分子机制研究进展
姜婧,张瑶,蒋芮,李雅婷,宋立华*
0
(上海交通大学农业与生物学院食品科学与工程系, 上海 200240
*通信作者)
摘要:
炎症与氧化应激是多种疾病病理过程的2个方面,它们互相促进,造成疾病的恶性循环。富氢水是富含氢气的水,研究表明,富氢水可选择性清除过量羟自由基,有效减轻机体氧化损伤,在不同病理状态下减轻组织的炎性损伤。近年来研究发现,富氢水可以改善类风湿关节炎、结肠炎、肝炎、胰腺炎等多种炎性状态,其抗炎作用的发挥与减轻氧化应激损伤和参与p38-MAPK、NF-κB等信号转导通路的调控有关。本文就富氢水的抗炎活性及其作用机制作一综述。
关键词:    富氢水  炎性疾病  抗炎活性  抗氧化活性  信号通路
DOI:10.16781/j.0258-879x.2020.07.0798
投稿时间:2019-10-07修订日期:2020-03-03
基金项目:上海市科技兴农项目(2019-02-08-00-08-F01154).
Anti-inflammatory activity and molecular mechanisms of hydrogen-rich water: recent progress
JIANG Jing,ZHANG Yao,JIANG Rui,LI Ya-ting,SONG Li-hua*
(Department of Food Science&Technology, Shanghai Jiao Tong University School of Agriculture and Biology, Shanghai 200240, China
*Corresponding author)
Abstract:
Inflammation and oxidative stress are two aspects of the pathology of many diseases, and they also promote each other, causing a vicious cycle of the disease. Hydrogen-rich water is the water rich in hydrogen. Studies have proved that hydrogen-rich water can selectively reduce hydroxyl radicals and ameliorate oxidative and inflammatory injuries to organs and tissues under different pathological conditions. In recent years, it has been found that hydrogen-rich water can improve the inflammatory conditions of rheumatoid arthritis, colitis, hepatitis, pancreatitis, etc. Its anti-inflammatory effects are related to the amelioration of oxidative stress and regulation of the signal transduction pathways such as p38-mitogen-activated protein kinase (p38-MAPK) and nuclear factor κB (NF-κB). In the present review, the anti-inflammatory activity of hydrogen-rich water and its molecular mechanisms are summarized and discussed.
Key words:  hydrogen  hydrogen-rich water  inflammatory diseases  anti-inflammatory activity  antioxidant activity  signaling pathway