| 摘要: |
| 蛋白酪氨酸磷酸化修饰广泛存在于真核细胞内，作为一种基础调节机制参与调节细胞的增殖、凋亡、分化、迁移等多个生命过程。蛋白酪氨酸磷酸化改变可影响肝脏炎症、肝纤维化、肝癌等多种肝脏疾病。含SH2结构域的蛋白酪氨酸磷酸酶1（SHP-1）属于非受体型蛋白酪氨酸磷酸酶，是维持体内蛋白酪氨酸磷酸化水平的关键因子。近年来SHP-1在肝脏疾病中的研究取得了重大进展，本文主要就SHP-1在肝脏疾病中的研究现状作一综述。 |
| 关键词: 含SH2结构域的蛋白酪氨酸磷酸酶类 酪氨酸磷酸化 肝脏疾病 |
| DOI：10.16781/j.0258-879x.2017.09.1128 |
| 投稿时间：2017-03-23修订日期：2017-06-08 |
| 基金项目:国家自然科学基金（81400895）. |
|
| Research status of src-homology 2 domain-containing protein tyrosine phosphatase 1 in liver diseases |
| LEI Shu-juan,WEN Liang-zhi,ZHANG Xin,XIE Wei-fen* |
(Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Protein tyrosine phosphorylation is ubiquitously found in eukaryotic cells, and it is a fundamental regulatory mechanism to be involved in the regulation of cell proliferation, apoptosis, differentiation and migration. Dysregulation of protein tyrosine phosphorylation can influence various liver diseases, such as liver inflammation, liver fibrosis and liver cancer. The src-homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), a nonreceptor type protein tyrosine phosphatase, is a key regulator of maintaining protein tyrosine phosphorylation level in vivo. Recently, great progress in the research of SHP-1 in liver diseases has been made, and this review summed up the advances of SHP-1 in liver diseases. |
| Key words: SH2 domain-containing protein tyrosine phosphatases tyrosine phosphorylation liver diseases |
