摘要: |
氧化应激损伤是导致疾病的一个重要因素。间充质干细胞来源外泌体(MSC-exo)含有多种蛋白质、脂质、编码RNA及非编码RNA,可通过多种途径减轻机体的氧化应激损伤,促进受损的组织细胞修复再生,因此MSC-exo在氧化应激所致疾病的治疗中有巨大的发展潜力。本文对MSC-exo在减轻氧化应激导致的心血管损伤、肺组织损伤、肾脏损伤、肝细胞损伤等方面的研究进展作一综述。 |
关键词: 间充质干细胞 外泌体 氧化性应激 损伤修复 |
DOI:10.16781/j.0258-879x.2018.07.0716 |
投稿时间:2018-02-09修订日期:2018-06-21 |
基金项目:国家自然科学基金面上项目(81670741),国家自然科学基金青年项目(81701199),长海医院“1255”学科建设计划科研创新探索项目(CH125541900). |
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Research progress of mesenchymal stem cell-derived exosomes in oxidative stress injury |
ZHAI Xiao1,WANG Yi-ran2,ZHU Ming-xiang2,WANG Qi-jin3* |
(1. Department of Spine Surgery, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China; 2. The Third Student Team, College of Basic Medical Sciences, Navy Medical University(Second Military Medical University), Shanghai 200433, China; 3. Department of Endocrinology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China *Corresponding author) |
Abstract: |
Oxidative stress damage is known to be a major factor leading to many diseases. Mesenchymal stem cell-derived exosomes (MSC-exos) are enriched with various proteins, lipids, coding RNAs and non-coding RNAs, and alleviate oxidative stress damage and stimulate the regeneration response of damaged tissues and cells. MSC-exos hold a great potential for the treatment of diseases caused by oxidative stress. In this review, we summarized the research progress of MSC-exos in cardiovascular injury, lung injury, kidney injury and liver cell injury caused by oxidative stress. |
Key words: mesenchymal stem cells exosomes oxdative stress damage repair |