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间充质干细胞来源外泌体在氧化应激损伤中的研究进展
翟骁1,王一然2,朱明向2,王奇金3*
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(1. 海军军医大学(第二军医大学)长海医院脊柱外科, 上海 200433;
2. 海军军医大学(第二军医大学)基础医学院学员三大队, 上海 200433;
3. 海军军医大学(第二军医大学)长海医院内分泌科, 上海 200433
*通信作者)
摘要:
氧化应激损伤是导致疾病的一个重要因素。间充质干细胞来源外泌体(MSC-exo)含有多种蛋白质、脂质、编码RNA及非编码RNA,可通过多种途径减轻机体的氧化应激损伤,促进受损的组织细胞修复再生,因此MSC-exo在氧化应激所致疾病的治疗中有巨大的发展潜力。本文对MSC-exo在减轻氧化应激导致的心血管损伤、肺组织损伤、肾脏损伤、肝细胞损伤等方面的研究进展作一综述。
关键词:  间充质干细胞  外泌体  氧化性应激  损伤修复
DOI:10.16781/j.0258-879x.2018.07.0716
投稿时间:2018-02-09修订日期:2018-06-21
基金项目:国家自然科学基金面上项目(81670741),国家自然科学基金青年项目(81701199),长海医院“1255”学科建设计划科研创新探索项目(CH125541900).
Research progress of mesenchymal stem cell-derived exosomes in oxidative stress injury
ZHAI Xiao1,WANG Yi-ran2,ZHU Ming-xiang2,WANG Qi-jin3*
(1. Department of Spine Surgery, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. The Third Student Team, College of Basic Medical Sciences, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
3. Department of Endocrinology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Oxidative stress damage is known to be a major factor leading to many diseases. Mesenchymal stem cell-derived exosomes (MSC-exos) are enriched with various proteins, lipids, coding RNAs and non-coding RNAs, and alleviate oxidative stress damage and stimulate the regeneration response of damaged tissues and cells. MSC-exos hold a great potential for the treatment of diseases caused by oxidative stress. In this review, we summarized the research progress of MSC-exos in cardiovascular injury, lung injury, kidney injury and liver cell injury caused by oxidative stress.
Key words:  mesenchymal stem cells  exosomes  oxdative stress  damage repair