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| 中国优生及辅助生殖的挑战与出路 |
| 孙方臻1,2*,孙鹿希3,黄秀英1,张慧琴2,印惠荣2,颜宏利2,刘燕敏2,孙颖浩2 |
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(1. 中国科学院遗传与发育生物学研究所, 北京 100101;
2. 第二军医大学长海医院生殖医学中心, 上海 200433;
3. 清华大学医学院, 北京 100084
*通信作者) |
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| 摘要: |
| 人类辅助生殖技术给我国日益增长的不孕不育患者带来了希望，但同时也增加了后代出生缺陷甚至成人疾病的发生风险。本文阐述了影响优生的配子、胚胎、母源因素以及辅助生殖安全性，旨在强调提升下一代健康水平应以配子/胚胎健康为本，可借助基因组学新技术降低遗传性出生缺陷发生率，防控胚胎发育源性成年病风险。 |
| 关键词: 辅助生殖技术 先天畸形 基因组学 表观遗传 |
| DOI：10.16781/j.0258-879x.2017.07.0832 |
| 投稿时间：2017-06-29修订日期：2017-07-14 |
| 基金项目:国家科技部重大研究计划（2007CB948101，2012CB944903，2014CB964903）. |
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| Challenge and solution of eugenics and assisted reproduction in China |
| SUN Fang-zhen1,2*,SUN Lu-xi3,HUANG Xiu-ying1,ZHANG Hui-qin2,YIN Hui-rong2,YAN Hong-li2,LIU Yan-min2,SUN Ying-hao2 |
(1. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
2. Reproductive Medicine Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
3. School of Medicine, Tsinghua University, Beijing 100084, China
*Corresponding author) |
| Abstract: |
| Human assisted reproductive technology has brought hope to the growing infertility population, but also has increased the risk of birth defects and even adult disease incidence. Here we discussed the gametes, embryos and maternal factors which affect eugenics and assisted reproductive safety. With the help of the new genomics technology such as the next generation sequencing, we can greatly reduce the incidence of hereditary birth defects, and prevent and control embryonic developmental risk of adult diseases. |
| Key words: assisted reproductive techniques congenital abnormalities genomics epigenetics |
