| 摘要: |
| 白塞病是一种主要表现为复发性口腔溃疡、生殖器溃疡、眼炎和皮肤损害的慢性系统性血管炎。白塞病发病机制尚不明确，可能是遗传易感个体在感染或环境等因素触发下发生的自身免疫性疾病，辅助性T淋巴细胞17（Th17）在白塞病发病过程中有重要作用。干扰素调节因子8（IRF8）可抑制Th17分化，从而抑制Th17及白细胞介素17产生的炎性反应。基因组学研究提示，IRF8相关单核苷酸多态性位点是白塞病的风险基因位点。近年来，IRF8抑制Th17分化在白塞病发病机制中的作用已经成为研究热点。 |
| 关键词: 白塞病 Th 17细胞 干扰素调节因子8 白细胞介素17 单核苷酸多态性 |
| DOI：10.16781/j.0258-879x.2018.05.0535 |
| 投稿时间：2017-08-21修订日期：2017-09-07 |
| 基金项目:上海卫生系统第二批重要疾病联合攻关重点项目（2014ZYJB0010），上海申康医院发展中心临床科技创新项目（SHDC12017129）. |
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| Role of interferon regulatory factor 8 inhibiting helper T cell 17 differentiation in pathogenesis of Behçet's disease |
| LIN Chen-hong,GUAN Jian-long* |
(Department of Immunology and Rheumatology, Huadong Hospital, Fudan University, Shanghai 200040, China
*Corresponding author) |
| Abstract: |
| Behçet's disease (BD) is a chronic systemic vasculitis that mainly characterized by recurrent oral ulcers, genital ulcers, uveitis and skin lesions. The pathogenesis of BD is still unknown. BD is considered to be an autoimmune disease triggered by infection or environmental factors in genetically susceptible individuals. Helper T cell 17 (Th17) play an important role in the pathogenesis of BD. Interferon regulatory factor 8 (IRF8) inhibits Th17 differentiation, thereby inhibiting the inflammation induced by Th17 and interleukin 17. Genomic studies suggest that IRF8-associated single nucleotide polymorphisms (SNPs) are risk loci of BD. In recent years, role of IRF8 inhibiting Th17 differentiation in the pathogenesis of BD has become a research focus. |
| Key words: Behçet's disease Th17 cells interferon regulatory factor 8 interleukin 17 single nucleotide polymorphism |
