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| 巨噬细胞在骨折愈合过程中作用的研究进展 |
| 周潇逸1,吴随一2,张子程1,王飞1,杨依林1,徐锡明3,李明1,魏显招1* |
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(1. 第二军医大学长海医院脊柱外科, 上海 200433;
2. 第二军医大学学员旅学员3 队, 上海 200433;
3. 第二军医大学长征医院脊柱外科, 上海 200003
*通信作者) |
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| 摘要: |
| 炎性反应对骨折愈合初期血肿形成、组织碎片清除及纤维组织生成具有重要作用。M1、M2型巨噬细胞分别通过促炎、抗炎作用参与骨折愈合过程。巨噬细胞分泌的肿瘤坏死因子α、白细胞介素等细胞因子可调节成骨/破骨细胞活性。骨组织生物工程学研究通过功能型组织工程调节骨折局部炎性反应，可促进血管新生及骨折愈合。因此，探究巨噬细胞在骨折愈合过程中的作用可以为促进骨折愈合提供新思路。 |
| 关键词: 组织工程 巨噬细胞 骨折 炎症 愈合 |
| DOI：10.16781/j.0258-879x.2017.12.1556 |
| 投稿时间：2017-09-24修订日期：2017-10-17 |
| 基金项目:国家自然科学基金（81301554），上海市自然科学基金（13ZR1450200），上海市卫生与计划生育委员会科研课题（20154Y0018）. |
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| Research progress on role of macrophage in fracture healing |
| ZHOU Xiao-yi1,WU Sui-yi2,ZHANG Zi-cheng1,WANG Fei1,YANG Yi-lin1,XU Xi-ming3,LI Ming1,WEI Xian-zhao1* |
(1. Department of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. The Third Student Team, Student Brigade, Second Military Medical University, Shanghai 200433, China;
3. Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Inflammatory reaction plays an important role in hematoma formation, tissue debris removal and fibrous tissue formation during the first stage of fracture healing. M1 and M2 macrophages participate in the process of fracture healing through pro-inflammatory and anti-inflammatory effects, respectively. Tumor necrosis factor α, interleukin and other cytokines secreted by macrophages can regulate the activities of osteoblasts and osteoclasts. Bone tissue bioengineering studies found that functional tissue engineering can promote angiogenesis and fracture healing by regulating inflammatory reaction. Therefore, exploring the role of macrophages in the process of fracture healing may provide new insights for promoting fracture healing. |
| Key words: tissue engineering macrophage fracture inflammation healing |
