| 摘要: |
| 氢气是一种无色、无味、具有生物活性的还原性小分子气体，可与机体内的活性氧发生反应。目前认为氢气具有抗氧化、抗炎、抗凋亡等生物学作用，且氢气具有极高生物安全性。近年来氢气相关研究的范围不断扩大，氢气应用的模型从急性病到慢性病、从良性病到恶性病都有所涉及。此外，氢气应用的手段也在逐渐丰富，包括氢气吸入、氢水饮用、含氢溶液静脉注射或局部使用以及含氢透析液透析等。与此同时逐渐增多的临床研究也进一步证明，氢气在疾病治疗方面的重要作用和独特优势。然而，氢气生物学效应的分子机制目前仍未阐明，许多学者和普通大众对氢气生物学效应的研究进展缺乏了解，这限制了氢气医学的发展及相关产品的研发，氢气医学的研究和普及依然任重而道远。 |
| 关键词: 氢 抗氧化剂 作用机制 临床研究 |
| DOI：10.16781/j.0258-879x.2018.11.1181 |
| 投稿时间：2018-06-06修订日期：2018-10-29 |
| 基金项目:国家自然科学基金（81371316）. |
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| Hydrogen medicine: research advance, controversy and challenges |
| LU Hong-tao,SUN Xue-jun* |
(Department of Naval Aeromedicine, Faculty of Naval Medicine, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Hydrogen is colorless and odorless small molecule gas with biological activity, and it can react with reactive oxygen species. It is believed that hydrogen has biological effects such as anti-oxidation, anti-inflammation and anti-apoptosis, and has extremely high biosafety. Recently, hydrogen application has been involved in various acute and chronic diseases, and benign and malignant diseases. In addition, means of hydrogen utilization is also enriched, including hydrogen inhalation, hydrogen-rich water drinking, intravenous injection or partial use of hydrogen-rich saline and dialysis of hydrogen-rich dialysate. More importantly, the increasing hydrogen-related clinical studies have further demonstrated that hydrogen is effective and safe for diseases. However, the molecular mechanism of hydrogen biological effects is not very clear, and many scholars and the general public lack an understanding of hydrogen development status, which limits the development of hydrogen medicine and the related products. The research and popularization of hydrogen medicine is still a work in progress. |
| Key words: hydrogen antioxidants mechanism clinical research |
