| 摘要: |
| 强直性脊柱炎（AS）是以骶髂关节和脊柱关节受累为主的免疫介导的慢性炎症性疾病，其主要病理特点为附着点炎和新骨形成导致关节融合，目前发病机制尚不明确。Wnt信号通路在正常骨稳态特别是成骨细胞新骨形成中尤为关键，可能在AS发病机制中发挥重要作用。研究表明慢性炎症和遗传调控能够通过Wnt信号通路共同参与AS新骨形成。本文主要就近年来Wnt/β-catenin信号通路在AS骨代谢中的影响作一综述。 |
| 关键词: 强直性脊柱炎 Wnt信号通路 β-连环蛋白 成骨 |
| DOI：10.16781/j.0258-879x.2019.04.0435 |
| 投稿时间：2019-02-26修订日期：2019-04-02 |
| 基金项目:国家重点基础研究发展计划（2014CB541802），国家自然科学基金面上项目（31770988）. |
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| Advances on Wnt/β-catenin signaling pathway in osteogenesis of ankylosing spondylitis |
| GAO Li-hong,LIU Xin,WU Xin,XU Hu-ji* |
(Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University(Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Ankylosing spondylitis (AS) is an immune-mediated chronic inflammatory disease characterized by involvement of sacroiliac and spinal joints. The main pathological features of AS are enthesitis and new bone formation-caused joint fusion, but its pathogenesis is still unclear. Wnt signaling pathway exerts an important effect on the normal bone homeostasis, especially on the formation of osteoblasts, and may contribute to the pathogenesis of AS. Studies have shown that chronic inflammation and genetic regulation participate in the new bone formation of AS through Wnt signaling pathway. This review sums up the effect of Wnt/β-catenin signaling pathway on bone metabolism of AS in recent years. |
| Key words: ankylosing spondylitis Wnt signaling pathway β-catenin osteogenesis |
