| 摘要: |
| 慢性胰腺炎继发胰腺外分泌功能不全（PEI）严重影响患者的生活质量。PEI目前尚无单一的、可广泛应用的诊断方法，需根据患者的临床表现、胰腺外分泌功能、营养状态等多方面综合考虑做出诊断。PEI的主要治疗方法为胰酶替代治疗（PERT），此外还需配合营养状态改善和生活方式调整。PERT过程中应通过观察患者的临床表现、检测血清营养物质含量等监测疗效，对于PERT疗效欠佳者需仔细分析原因以制订合理的对策。 |
| 关键词: 慢性胰腺炎 胰腺外分泌功能不全 胰酶 酶替代治疗 |
| DOI：10.16781/j.0258-879x.2021.02.0203 |
| 投稿时间：2019-04-09修订日期：2019-08-28 |
| 基金项目:国家自然科学基金（81470883，81770635），上海市青年科技启明星计划（17QA1405500），上海青年拔尖人才开发计划（HZW2016FZ67），上海市卫生和计划生育委员会智慧医疗专项科研项目（2018ZHYL0229）. |
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| Pancreatic exocrine insufficiency in chronic pancreatitis patients: diagnosis and treatment |
| LIU Yu1,2,HU Liang-hao1* |
(1. Department of Gastroenterology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Gastroenterology, General Hospital of PLA Eastern Theater Command, Nanjing 210002, Jiangsu, China
*Corresponding author) |
| Abstract: |
| Pancreatic exocrine insufficiency (PEI) secondary to chronic pancreatitis seriously affects the quality of life of the patients. There is no single and widely used method for diagnosis of PEI. Diagnosis of PEI should be based on the clinical manifestations, pancreatic exocrine function tests, nutritional status and other aspects. Pancreatic enzyme replacement therapy (PERT) is the main treatment of PEI, which should be combined with improved nutritional status and lifestyle. Therapeutic effect should be monitored during PERT by observing the clinical manifestations, detecting the content of serum nutrients and so on. For the patients with poor prognosis after PERT, it is necessary to carefully analyze the causes to formulate a reasonable countermeasure. |
| Key words: chronic pancreatitis pancreatic exocrine insufficiency pancreatin enzyme replacement therapy |
