| 摘要: |
| 持续性姿势感知性眩晕（PPPD）是临床上最常见的头晕类型之一，具有与焦虑、抑郁等情绪障碍密切相关和视觉依赖2个临床特点，但发病机制尚不明确，缺乏客观检查手段，极易误诊。近年来神经影像学技术的发展为进一步探究PPPD的病理生理机制提供了重要手段。本文通过分析近年PPPD患者静息态、任务态及结构功能磁共振成像的研究进展，发现PPPD的2个临床特点可能与相关脑区结构或功能变化有关，这为PPPD的诊疗提供了新的思路。 |
| 关键词: 精神性头晕 持续性姿势感知性眩晕 慢性主观性头晕 神经影像学 功能磁共振成像 |
| DOI：10.16781/j.0258-879x.2020.04.0439 |
| 投稿时间：2019-09-03修订日期：2019-12-18 |
| 基金项目:上海市卫生系统优秀人才培养计划（优秀学科带头人）（2018BR29），海军军医大学（第二军医大学）长海医院青年启动基金（2018QNA010）． |
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| Functional magnetic resonance imaging in persistent postural-perceptual dizziness: an advance |
| CHEN Chao,FAN Cun-xiu,BI Xiao-ying* |
(Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Persistent postural-perceptual dizziness (PPPD) is one of the most common types of dizziness in the clinic.It has two characteristics: close relation with emotional disorders (anxiety and depression) and visual dependence, but its pathogenesis is still not clear. Due to lack of objective examination methods, it is easy to be misdiagnosed. In recent years, the development of neuroimaging helps us to further explore the pathophysiological mechanism of PPPD. This paper reviews the progress in neuroimaging studies on resting-state functional magnetic resonance imaging, task-state functional magnetic resonance imaging, and structural functional magnetic resonance imaging in patients with PPPD. It is found that the two characteristics of PPPD may be related to the changes in structure or function of related brain areas, which provides new insights for the diagnosis and treatment of PPPD. |
| Key words: psychogenic dizziness persistent postural-perceptual dizziness chronic subjective dizziness neuroimaging functional magnetic resonance imaging |
