| 摘要: |
| 双相磷酸钙材料是骨重建手术中替代材料的“金标准”，其制备方法多为人工合成，但人工合成方法制备工序复杂、孔径分布不可控、成本较高，同时生物活性较低。研究发现海洋鱼骨作为一种天然骨来源也可用于制备双相磷酸钙材料，其来源广泛、制备方法简单、β-磷酸三钙含量高，并保留了天然的微观孔隙结构，是一种潜在的骨替代支架材料。本文从制备方法和材料表征方面综述了海洋鱼骨来源制备双相磷酸钙材料的研究进展。 |
| 关键词: 骨替代材料 双相磷酸钙 海洋鱼骨 制备 表征 |
| DOI：10.16781/j.0258-879x.2020.02.0206 |
| 投稿时间：2019-09-26修订日期：2019-10-06 |
| 基金项目:国家自然科学基金（81870808）. |
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| Research progress of preparation of biphasic calcium phosphate ceramics from marine fish bone |
| CHEN Hai-wen,WANG Shao-hai,ZHU Qing-feng,DOU Wen-xue,TANG Wei-zhong* |
(Department of Stomatology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| The biphasic calcium phosphate material is the golden standard alternative materials in bone reconstruction operation. It is mostly from artificially synthesized, but the method is featured by intricate preparation process, uncontrollable pore size distribution, high cost, and low biological activity. Some researches have found that marine fish bone, as a natural bone source, can also be used to prepare biphasic calcium phosphate materials. With a wide range of sources, simple preparation methods and high content of β-tricalcium phosphate, it retains the natural microscopic pore structure, making it a potential bone replacement support material. In this paper, the research progress on biphasic calcium phosphate material from marine fish bone is reviewed regarding preparation methods and material characterization. |
| Key words: bone substitutes biphasic calcium phosphate marine fish bone preparation characterization |
