| 摘要: |
| 目的 分析痛风患者血清糖类抗原724（CA724）水平升高的临床意义。方法 回顾性分析2016年7月至2019年6月于我院就诊的271例痛风、63例强直性脊柱炎、40例银屑病性关节炎、67例骨关节炎患者和280名健康对照的临床资料。比较痛风患者与强直性脊柱炎、银屑病性关节炎、骨关节炎和健康对照的血清CA724阳性率及水平。根据临床症状、体征，将痛风患者分为急性发作期（n=53）、慢性期（n=218）两组，比较两组间CA724水平的差异，并分析急性发作期痛风患者血清CA724水平与白细胞计数、CRP的相关性。根据血清CA724水平，将痛风患者分为CA724水平升高组（n=63）和CA724水平正常组（n=208），比较两组间血尿酸、三酰甘油、高密度脂蛋白水平的差异。结果 痛风患者血清CA724阳性率高于强直性脊柱炎、银屑病性关节炎、骨关节炎和健康对照（P<0.05，P<0.01），痛风患者血清CA724水平高于骨关节炎患者和健康对照（P<0.05，P<0.01）。急性发作期痛风患者的血清CA724水平高于慢性期患者（P<0.01），急性发作期痛风患者血清CA724水平与白细胞计数、CRP水平均呈正相关（P均<0.01）。血清CA724水平升高痛风患者的血尿酸水平、三酰甘油水平高于CA724水平正常者（P<0.01，P<0.05），血高密度脂蛋白水平低于CA724水平正常者（P<0.01）。结论 部分痛风患者的血清CA724水平会升高，且其与痛风急性发作、炎症反应有关。 |
| 关键词: 痛风 糖类抗原CA724 白细胞计数 C-反应蛋白 |
| DOI：10.16781/j.0258-879x.2020.09.1041 |
| 投稿时间：2019-11-05修订日期：2020-05-29 |
| 基金项目:上海市浦江风湿青年医师培育计划（SPROG201809）． |
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| Abnormal elevation of serum carbohydrate antigen 724 in gout patients |
| WANG Xiu-wen,BIAN Jian-ye,LI Ting,ZHOU Ling,XU Hu-ji* |
(Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University(Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To analyze the clinical significance of elevated serum carbohydrate antigen 724 (CA724) in gout patients. Methods The clinical data of 271 gout patients, 63 ankylosing spondylitis patients, 40 psoriatic arthritis patients, 67 osteoarthritis patients and 280 healthy controls in our hospital from Jul. 2016 to Jun. 2019 were retrospectively analyzed. The positive rates and levels of serum CA724 were compared among gout patients and ankylosing spondylitis patients, psoriatic arthritis patients, osteoarthritis patients and healthy controls. According to the clinical symptoms and signs, gout patients were also divided into acute-stage group (n=53) and chronic-stage group (n=218); the serum CA724 levels were compared between the two groups and the correlation between serum CA724 level with white blood cell count and C-reactive protein (CRP) was analyzed in acute-stage gout patients. According to the serum CA724 level, gout patients were divided into elevated serum CA724 group (n=63) and normal serum CA724 group (n=208), and the serum uric acid, triglyceride, and high-density lipoprotein were compared between the two groups. Results The positive rate of serum CA724 in gout patients was significantly higher than those in ankylosing spondylitis patients, psoriatic arthritis patients, osteoarthritis patients and healthy controls (P<0.05, P<0.01). Serum CA724 in gout patients was significantly higher than those in osteoarthritis patients and healthy controls (P<0.05, P<0.01). Serum CA724 in acute-stage gout patients was significantly higher than that in chronic-stage gout patients (P<0.01), and it was positively correlated with white blood cell count and CRP (both P<0.01). The levels of serum uric acid and triglyceride in gout patients with elevated serum CA724 were significantly higher than those in patients with normal serum CA724 (P<0.01, P<0.05), while the level of high-density lipoprotein was significantly lower than that in normal serum CA724 group (P<0.01). Conclusion Serum CA724 level is increased in some gout patients, and serum CA724 is correlated with acute gout attack and inflammation. |
| Key words: gout carbohydrate antigen 724 leukocyte count C-reactive protein |
