| 摘要: |
| 我国是消化道肿瘤高发国家，以胃癌、食管癌和结肠癌为代表的三大消化道肿瘤严重威胁着我国人民的健康水平，也造成了沉重的医疗负担。本文从近年来国家颁布的相关政策入手，分别针对胃癌、食管癌、结肠癌和胰腺癌的筛查流程加以评述，评估胃癌的血清胃蛋白酶原联合胃泌素检测、结肠癌的粪便和血液基因检测、胰腺癌的"血清液体活组织检查"等新技术对早癌的筛查效果，并提出消化道早癌筛查工作现阶段存在的困难和挑战。通过回顾和展望，进一步明确了推动消化道早癌筛查行动和研究对于降低我国消化道肿瘤病死率的重要意义。 |
| 关键词: 胃肿瘤 食管肿瘤 结肠肿瘤 筛查 早期诊断 血清学标志物 |
| DOI：10.16781/j.0258-879x.2020.01.0001 |
| 投稿时间：2020-01-07修订日期：2020-01-12 |
| 基金项目: |
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| Challenges and prospects for early gastrointestinal cancer screening in China |
| DU Yi-qi,LI Zhao-shen* |
(Department of Gastroenterology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| China is a country with high incidence of gastrointestinal (GI) cancer. Gastric cancer, esophageal cancer and colon cancer seriously threaten the health of people, and leads to heavy medical burdens. This review discusses the current screening protocol of GI cancer and pancreatic cancer. It also interprets the relevant policies issued by the state in recent years, and evaluates the effects of new technologies such as serum pepsinogen combined with gastrin in detecting gastric cancer, fecal and blood gene detection for colon cancer, and "serum liquid biopsy" of pancreatic cancer for early cancer screening. We also point out the difficulties and challenges in cancer screening at early stage, and the significance of promoting early cancer screening to reduce the mortality of GI cancer in China. |
| Key words: stomach neoplasms esophageal neoplasms colonic neoplasms screening early diagnosis serum biomarkers |
