| 摘要: |
| 目的 探讨二维相位对比磁共振成像（2D PC-MRI）定量监测正常吸烟人群肺动脉血流动力学的可行性，以及不同吸烟程度对肺动脉血流动力学的影响。方法 选择2019年5月至2020年1月在我院行心脏2D PC-MRI检查的正常男性吸烟志愿者49名，记录吸烟参数（吸烟强度、吸烟时间、吸烟负担）。采用2D PC-MRI测量肺动脉主干血流动力学参数，包括正向峰值流速（PPV）、负向峰值流速（PNV）、平均血流量（AF）、平均正向血流量（APF）、平均负向血流量（ANF）。使用组内相关系数（ICC）对肺动脉主干血流动力学参数进行组内、组间一致性分析，同时分析吸烟参数与肺动脉主干血流动力学参数的相关性，以及非重度吸烟组（吸烟时间<20年，n=24）与重度吸烟组（吸烟时间≥ 20年，n=25）志愿者肺动脉主干血流动力学参数的差异。结果 肺动脉主干血流动力学参数PPV、PNV、AF、APF、ANF的组内、组间ICC值为0.890~0.987，说明一致性良好。吸烟时间与肺动脉主干PPV、AF、APF呈负相关（r=-0.321、-0.350、-0.311，P=0.024、0.014、0.029）。重度吸烟组的肺动脉主干PPV、AF、APF均低于非重度吸烟组（P均<0.05）。结论 2D PC-MRI技术能够用于监测正常人群不同吸烟程度对肺动脉主干血流动力学的影响，肺动脉主干正向血流动力学参数（PPV、AF、APF）均随着吸烟时间延长而降低，尤其是重度吸烟者。 |
| 关键词: 吸烟 二维相位对比法 磁共振成像 肺动脉 血流动力学 |
| DOI：10.16781/j.0258-879x.2020.11.1289 |
| 投稿时间：2020-04-07修订日期：2020-06-11 |
| 基金项目:辽宁省教育厅科研基金（L2016021）. |
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| Evaluation of pulmonary arterial hemodynamics changes in normal smoking population by two-dimensional phase contrast magnetic resonance imaging |
| MA Shuang-chun,LI Xin,CHE Si-yu,SONG Qing-wei,LIU Ai-lian,LI Zhi-yong* |
(Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China
*Corresponding author) |
| Abstract: |
| Objective To explore the feasibility of two-dimensional phase contrast magnetic resonance imaging (2D PC-MRI) for quantitatively monitoring the pulmonary arterial hemodynamics in normal population, and evaluate the influence of different levels of smoking status on pulmonary hemodynamics in normal population. Methods A total of 49 normal male smoking volunteers who underwent pulmonary artery 2D PC-MRI examinations in our hospital from May 2019 to Jan. 2020 were included in the study, and smoking parameters (smoking intensity, smoking time, and smoking burden) were recorded. The hemodynamic parameters of the main pulmonary artery were measured by 2D PC-MRI, including positive peak velocity (PPV), negative peak velocity (PNV), average blood flow (AF), average positive blood flow (APF) and average negative blood flow (ANF). Intraclass correlation coefficient (ICC) was used to analyze the intra- and inter-group consistency of hemodynamic parameters. The correlation between smoking parameters and hemodynamic parameters was analyzed. The differences of hemodynamic parameters between non-heavy smoking group (smoking time <20 years, n=24) and heavy smoking group (smoking time ≥ 20 years, n=25) were also analyzed. Results The intra- and inter-group ICC values of PPV, PNV, AF, APF and ANF were 0.890-0.987, indicating good consistency. Smoking time was negatively correlated with PPV, AF and APF, respectively (r=-0.321, -0.350, -0.311; P=0.024, 0.014, 0.029). PPV, AF and APF of the heavy smoking group were significantly lower than those of the non-heavy smoking group (all P<0.05). Conclusion The 2D PC-MRI technology can be used to monitor the influence of different smoking degrees on the main pulmonary hemodynamics in normal population. With the prolongation of smoking time, the main pulmonary artery positive flow parameters (PPV, AF and APF) decrease, especially in heavy smokers. |
| Key words: smoking two-dimensional phase contrast magnetic resonance imaging pulmonary artery hemodynamics |
