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| 非电离辐射损害男性生育功能生物学机制的研究现状 |
| 包业炜1,房晓2,甘欣欣2,晏睿1,刘冰2,王军凯2,王林辉*1 |
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(1. 海军军医大学(第二军医大学)第一附属医院泌尿外科, 上海 200433;
2. 海军军医大学(第二军医大学)第二附属医院泌尿外科, 上海 200003
*通信作者) |
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| 摘要: |
| 越来越多的证据表明，长期暴露于某些非电离辐射（NIR）是诱发癌症、男性不育等疾病的危险因素。研究表明NIR对精子参数及激酶在生殖细胞代谢与内分泌系统中的作用均有不利影响，且会产生遗传毒性、基因组不稳定性和氧化应激。然而NIR作用于男性性腺造成不育的生物学、分子生物学机制尚不清楚。本文总结NIR造成男性不育机制的生物医学研究，从NIR对生殖内分泌系统、精子激酶活性和氧化还原平衡的影响及其诱发的细胞凋亡、DNA损伤和表观遗传学改变等方面进行阐述，并对该领域未来研究进行展望。 |
| 关键词: 非电离辐射 性腺 男性不育 生物学机制 |
| DOI：10.16781/j.CN31-2187/R.20200875 |
| 投稿时间：2020-06-17修订日期：2021-08-27 |
| 基金项目: |
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| Biological mechanism of male infertility caused by non-ionizing radiation:research status |
| BAO Ye-wei1,FANG Xiao2,GAN Xin-xin2,YAN Rui1,LIU Bing2,WANG Jun-kai2,WANG Lin-hui1 |
(1. Department of Urology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Urology, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Increasing evidence shows that long-term exposure to non-ionizing radiation (NIR) is a risk factor for cancer, male infertility and other diseases. Current studies have revealed the adverse effects of NIR on sperm parameters and on the role of kinases in germ cell metabolism and endocrine system, and can lead to genotoxicity, genomic instability and oxidative stress. However, the biological and molecular mechanisms of infertility caused by NIR on male reproductive organs are still not clear. The purpose of this review is to summarize the current biomedical research on the mechanism of male infertility caused by NIR, discuss the effects of NIR on reproductive endocrine system, sperm kinase activity and redox balance, as well as apoptosis, DNA damage and epigenetic changes induced by NIR, and look into the future research in this field. |
| Key words: non-ionizing radiation gonad male infertility biological mechanism |
