| 摘要: |
| 目的 探讨以68镓（68Ga）标记的靶向前列腺特异性膜抗原（PSMA）分子探针PSMA-11为示踪剂的PET-CT（68Ga-PSMA-11 PET-CT）检测初诊前列腺癌患者的阳性发现情况。方法 回顾性分析2019年1月至12月经前列腺活体组织穿刺病理学初次确诊、于海军军医大学（第二军医大学）长海医院行68Ga-PSMA-11 PET-CT检查的45例前列腺癌患者的影像学及临床资料。采用二分类判别法定性分析68Ga-PSMA-11 PET-CT图像，以诊断前列腺癌原发灶是否累及前列腺两叶、突破包膜、侵犯精囊和发生区域淋巴结转移。以根治性切除术标本的病理学结果为金标准，对影像-病理的配对样本进行McNemar检验，并计算Kappa系数。结果 68Ga-PSMA-11 PET-CT检测初诊前列腺癌患者的原发灶累及前列腺两叶、突破包膜、侵犯精囊和发生区域淋巴结转移的准确度分别为60.0%（27/45）、57.8%（26/45）、75.6%（34/45）和84.4%（38/45），Kappa系数分别为0.075（P=0.375）、0.249（P=0.025）、0.409（P=0.003）和0.444（P=0.002）。结论 68Ga-PSMA-11 PET-CT对判断初诊前列腺癌患者病灶是否存在侵犯精囊和发生区域淋巴结转移有一定价值，但对是否累及前列腺两叶和突破包膜的诊断价值较低。 |
| 关键词: 前列腺肿瘤 前列腺特异性膜抗原 正电子发射断层显像计算机体层摄影术 68镓 |
| DOI：10.16781/j.0258-879x.2021.04.0361 |
| 投稿时间：2020-10-29修订日期：2021-01-04 |
| 基金项目:上海市卫生健康委员会先进适宜技术推广项目（2019SY029），海军军医大学（第二军医大学）长海医院"234学科攀峰计划"（2019YPT002，2020YPT002）. |
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| Evaluation of 68Ga-PSMA-11 PET-CT for positive findings in patients with newly diagnosed prostate cancer |
| WEN Jian-nan1,2,CHENG Chao1,ZHANG Ze-yu1,LI Rou1,GU Zhen-yong1,ZUO Chang-jing1* |
(1. Department of Nuclear Medicine, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. The First Outpatient Department, General Hospital of PLA Northern Theater Command, Shenyang 110001, Liaoning, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the positive findings of 68gallium-labelled prostate-specific membrane antigen (PSMA) ligand PSMA-11 (68Ga-PSMA-11) positron emission tomography-computed tomography (PET-CT) in patients with newly diagnosed prostate cancer. Methods The imaging and clinical data of 45 patients with prostate cancer newly diagnosed by biopsy who undergoing 68Ga-PSMA-11 PET-CT in Changhai Hospital of Naval Medical University (Second Military Medical University) from Jan. to Dec. 2019 were retrospectively analyzed. The 68Ga-PSMA-11 PET-CT images were qualitatively analyzed by binomial classification to observe the involvement of prostate bilobes, capsule, seminal vesicles and regional lymph nodes. With the pathology result of radical prostatectomy as the gold standard, the McNemar test of image-pathology paired samples was carried out, and the Kappa coefficient was calculated. Results The accuracy rates of 68Ga-PSMA-11 PET-CT in detecting primary lesions involving prostate bilobes, capsule, seminal vesicles and regional lymph nodes were 60.0% (27/45), 57.8% (26/45), 75.6% (34/45) and 84.4% (38/45), respectively, and the Kappa coefficients were 0.075 (P=0.375), 0.249 (P=0.025), 0.409 (P=0.003) and 0.444 (P=0.002), respectively. Conclusion 68Ga-PSMA-11 PET-CT has a value in detecting involvement of seminal vesicles and regional lymph nodes in patients with newly diagnosed prostate cancer, but has a low value in detecting involvement of prostate bilobes and capsule. |
| Key words: prostatic neoplasms prostate-specific membrane antigen positron emission tomography-computed tomography 68gallium |
