【打印本页】 【下载PDF全文】 【HTML】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 868次   下载 629 本文二维码信息
码上扫一扫!
白细胞介素18的生理作用及其与妇科生殖疾病的相关性研究进展
丁杰,梅珊珊,程雯,俞超芹*
0
(海军军医大学(第二军医大学)第一附属医院中医妇科, 上海 200433
*通信作者)
摘要:
IL-18属于IL-1家族,是一种多效性免疫调节因子。IL-18通过诱导γ干扰素发挥强烈的促炎作用,并与多种生殖相关妇科疾病存在关联。本文综述了IL-18的生理作用及其与妇科生殖疾病的相关性,从子宫内膜容受性、卵泡发育、生殖免疫等方面探讨IL-18对女性生殖生理的影响。
关键词:  白细胞介素18  子宫内膜异位症  多囊卵巢综合征  反复自然流产  子宫内膜容受性  卵泡发育  生殖免疫
DOI:10.16781/j.CN31-2187/R.20210002
投稿时间:2021-01-03修订日期:2021-08-26
基金项目:国家自然科学基金(81774352,81573755,81703874,81603646,81503604),上海市妇幼健康中医专项建设项目,上海市科学技术委员会中医引导项目(19401930200).
Physiological role of interleukin-18 and its correlation with gynecological reproductive diseases: research progress
DING Jie,MEI Shan-shan,CHENG Wen,YU Chao-qin*
(Department of Traditional Chinese Medicine (Gynecology), The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon γ and is associated with diverse reproductive related gynecological diseases. This article reviews the physiological role of IL-18 and its correlation with gynecological reproductive diseases, and discusses the impacts of IL-18 on female reproductive physiology from the perspective of endometrial receptivity, folliclar development, and reproductive immunity.
Key words:  interleukin-18  endometriosis  polycystic ovarian syndrome  recurrent spontaneous abortion  endometrial receptivity  follicular development  reproductive immunity