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| 铁死亡在急性呼吸窘迫综合征中的基础研究和临床应用进展 |
| 王培,郁景文,张立,奚望,薛小飞,张宇峰,肖健,杨潜,王志农* |
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(海军军医大学(第二军医大学)第二附属医院胸心外科, 上海 200003
*通信作者) |
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| 摘要: |
| 铁死亡是一种独特的调节性细胞死亡形式，特点是铁依赖的、脂质过氧化物的过量累积。铁死亡在形态学、生物学和遗传学等方面明显不同于凋亡、坏死、自噬及其他形式的细胞死亡。铁、脂肪、氨基酸代谢及其他信号通路与铁死亡密切相关。铁死亡与癌症、炎症、神经变性、肝肾损伤和缺血再灌注损伤等的病理过程密切相关。急性呼吸窘迫综合征（ARDS）是严重威胁人类生命健康的肺部炎症性疾病，发病率和死亡率高。近年来，人们对肺损伤发病机制和修复途径有了长足的认识，针对通气诱发肺损伤的疗法对ARDS患者是有益的，但仍缺乏有效的药物治疗方法。在全球范围内大流行的新型冠状病毒感染令ARDS的形势更加严峻，亟待进一步探索其在细胞、分子水平的机制并研发新的疗法。本文对铁死亡的定义、机制及其在ARDS中的基础研究和临床应用进展进行综述。 |
| 关键词: 铁死亡 急性呼吸窘迫综合征 肺损伤 代谢通路 |
| DOI：10.16781/j.CN31-2187/R.20210638 |
| 投稿时间：2021-06-27修订日期：2021-12-06 |
| 基金项目:上海市领军人才计划（2015044），海军军医大学（第二军医大学）第二附属医院“金字塔人才工程”——优秀青年医师（YQ681）. |
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| Progress of ferroptosis in acute respiratory distress syndrome: from basic to clinics |
| WANG Pei,YU Jingwen,ZHANG Li,XI Wang,XUE Xiaofei,ZHANG Yufeng,XIAO Jian,YANG Qian,WANG Zhinong* |
(Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Ferroptosis is a unique way of regulated cell death characterized by iron-dependent and excessive accumulation of lipid peroxides. It is greatly different from apoptosis, necrosis, autophagy, and other forms of cell death in morphology, biology, and genetics. The metabolism of iron, lipid and amino acid and other signaling pathways are closely related to ferroptosis. It is closely associated with the pathological processes of diseases such as cancer, inflammation, neurodegeneration, liver and kidney injury, and ischemia/reperfusion injury. Acute respiratory distress syndrome (ARDS) is an inflammatory disease of the lung that seriously threatens human life and health with high incidence and mortality. The pathways involved in lung injury pathogenesis and repair have been broadened in recent years. Therapies targeting ventilation-induced lung injury have consistently proven beneficial for ARDS patients, but there is still a lack of effective drug treatment. The global pandemic of the coronavirus disease 2019 has made ARDS even more severe. It is urgent to further explore its mechanism at cellular and molecular levels and develop new therapies. This article reviews the definition and mechanism of ferroptosis and its role in ARDS from basic to clinics. |
| Key words: ferroptosis acute respiratory distress syndrome lung injury metabolic pathway |
