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严重急性呼吸综合征冠状病毒2感染致神经系统损伤的研究现状
马佩佩1,洪帆1,徐涛1,陈菊祥2*
0
(1. 海军军医大学(第二军医大学)第二附属医院神经外科, 上海 200003;
2. 海军军医大学(第二军医大学)第一附属医院神经外科, 上海 200433
*通信作者)
摘要:
新型冠状病毒肺炎(COVID-19)除损伤呼吸系统外,还可累及神经系统,甚至造成严重的临床后果。本文从致病机制、临床症状及治疗预后3个方面阐述了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)对神经系统损伤的研究现状,系统性归纳了COVID-19神经系统病变的病理机制,为COVID-19的诊断和治疗提供新思路。
关键词:  严重急性呼吸综合征冠状病毒2  病理机制  神经系统损害  临床特征  诊断  治疗
DOI:10.16781/j.CN31-2187/R.20210777
投稿时间:2021-08-09修订日期:2021-09-29
基金项目:国家自然科学基金(81872072).
Nervous system injury caused by severe acute respiratory syndrome coronavirus 2:research status
MA Pei-pei1,HONG Fan1,XU Tao1,CHEN Ju-xiang2*
(1. Department of Neurosurgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China;
2. Department of Neurosurgery, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
In addition to damaging the respiratory system, coronavirus disease 2019 (COVID-19) can also affect the nervous system, and even cause serious clinical consequences. This paper expounds the research status of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on nervous system injury from 3 aspects: pathogenesis, clinical symptoms and treatment prognosis, and systematically summarizes the pathological mechanism of nervous system lesions caused by COVID-19, hoping to provide new ideas for the diagnosis and treatment of COVID-19.
Key words:  severe acute respiratory syndrome coronavirus 2  pathological mechanism  nervous system damage  clinical features  diagnosis  therapy