| 摘要: |
| 光声成像兼具结构与功能成像的特点，是目前医学影像技术研究的新热点，研究方向涵盖了微观的细胞分子和宏观的组织器官。光声成像可通过直接定量评估肌红蛋白血氧饱和度反映受损肌肉的修复状态，亦可在2D和3D模式下清晰显示关节软骨、滑膜、血管和骨组织的结构形态。在关节炎症检测中，光声成像可无创地评估软骨受损程度，并通过抗体与光声造影剂偶联精准地分辨炎症分子标志物分布的空间信息，有助于关节炎的诊断和进展分期。 |
| 关键词: 光声成像 骨骼肌 软组织损伤 关节炎 肌骨超声 |
| DOI：10.16781/j.CN31-2187/R.20211220 |
| 投稿时间：2021-12-06修订日期：2022-03-07 |
| 基金项目:国家自然科学基金（81501492），上海市自然科学基金（20ZR1457900）. |
|
| Photoacoustic imaging in musculoskeletal diseases: application and progress |
| DIAO Zong-ping1,ZHAO Jia-qi2* |
(1. Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
2. Department of Ultrasound, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai 200434, China
*Corresponding author) |
| Abstract: |
| Photoacoustic imaging (PAI) has the characteristics of both structural and functional imaging and is a new focus in medical imaging research at present. Its research direction covers microscopic cell molecules and macroscopic tissue and organs. PAI can quantitatively evaluate the oxygen saturation of myoglobin, which can reflect the repair status of damaged muscles; it can also clearly display 2D and 3D structure and morphology of the articular cartilage, synovium, blood vessels, and bone tissue; and the trials with patients affected by inflammatory arthritis have also suggested that PAI can detect the degree of cartilage damage non-invasively. Furthermore, by coupling the antibody with photoacoustic contrast agent, PAI can accurately distinguish the spatial information of molecular markers of inflammation, which is helpful to the diagnosis and staging of arthritis. |
| Key words: photoacoustic imaging skeletal muscle soft tissue injuries arthritis musculoskeletal ultrasound |
