| 摘要: |
| 心房颤动（AF）是临床最常见的心律失常之一，也是心血管疾病发病率和死亡率增加的重要原因。心外膜脂肪组织（EAT）是位于脏层心包和心肌之间的一种特殊脂肪组织，参与AF的发生与维持，但其作用机制尚未完全阐明。由EAT来源脂肪干细胞分泌的细胞外囊泡近年来受到研究者们的重视。本文主要从EAT的特点、定量检测及其与心肌结构和电重构的关系，特别是细胞外囊泡对AF发生的影响等方面进行综述，以期进一步认识AF的发病机制，为AF的治疗提供新思路。 |
| 关键词: 心外膜脂肪组织 心房颤动 心房重构 结构重构 电重构 |
| DOI：10.16781/j.CN31-2187/R.20211278 |
| 投稿时间：2021-12-20修订日期：2022-03-07 |
| 基金项目:上海市“领军人才”计划（2015044）. |
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| Role of epicardial adipose tissue in structural and electrical remodeling of myocardium in atrial fibrillation |
| RAO Jin,YANG Qian,WANG Zhi-nong* |
(Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Atrial fibrillation (AF), one of the most common arrhythmias, accounts greatly for the morbidity and mortality of cardiovascular diseases. Epicardial adipose tissue (EAT), a kind of special adipose tissue, is anatomically located between the visceral pericardium and myocardium. EAT is involved in the development and maintenance of AF, but the mechanisms have not been fully elaborated. EAT-derived extracellular vehicles (EVs) have gained much attention recently. This paper mainly reviews the characteristics and quantitative detections of EAT, especially the role of EVs in the development of AF and its relationship with myocardial structural and electrical remodeling, so as to provide new insights on the pathogenesis of AF and reference for the treatment of AF in the future. |
| Key words: epicardial adipose tissue atrial fibrillation atrial remodeling structural remodeling electrical remodeling |
